{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:08:19Z","timestamp":1792271299254,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK117007"],"award-info":[{"award-number":["R01DK117007"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R00HL116776"],"award-info":[{"award-number":["R00HL116776"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01HL084207"],"award-info":[{"award-number":["P01HL084207"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Non\u2010alcoholic fatty liver disease, characterized in part by elevated liver triglycerides (i.e. hepatic steatosis), is a growing health problem.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In this study, we found that hepatic steatosis is associated with robust hepatic sympathetic overactivity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Removal of hepatic sympathetic nerves reduced obesity\u2010induced hepatic steatosis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Liver sympathetic innervation modulated hepatic lipid acquisition pathways during obesity.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) affects 1 in 3 Americans and is a significant risk factor for type\u00a0II diabetes mellitus, insulin resistance and hepatic carcinoma. Characterized in part by excessive hepatic triglyceride accumulation (i.e. hepatic steatosis), the incidence of NAFLD is increasing \u2013 in line with the growing obesity epidemic. The role of the autonomic nervous system in NAFLD remains unclear. Here, we show that chronic hepatic sympathetic overactivity mediates hepatic steatosis. Direct multiunit recordings of hepatic sympathetic nerve activity were obtained in high fat diet and normal chow fed male C57BL\/6J mice. To reduce hepatic sympathetic nerve activity we utilized two approaches including pharmacological ablation of the sympathetic nerves and phenol\u2010based hepatic sympathetic nerve denervation. Diet\u2010induced NAFLD was associated with a nearly doubled firing rate of the hepatic sympathetic nerves, which was largely due to an increase in efferent nerve traffic. Furthermore, established high fat diet\u2010induced hepatic steatosis was effectively reduced with pharmacological or phenol\u2010based removal of the hepatic sympathetic nerves, independent of changes in body weight, caloric intake or adiposity. Ablation of liver sympathetic nerves was also associated with improvements in liver triglyceride accumulation pathways including free fatty acid uptake and <jats:italic>de novo<\/jats:italic> lipogenesis. These findings highlight an unrecognized pathogenic link between liver sympathetic outflow and hepatic steatosis and suggest that manipulation of the liver sympathetic nerves may represent a novel therapeutic strategy for NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp277994","type":"journal-article","created":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T11:41:16Z","timestamp":1562413276000},"page":"4565-4580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Liver sympathetic denervation reverses obesity\u2010induced hepatic steatosis"],"prefix":"10.1113","volume":"597","author":[{"given":"Chansol","family":"Hurr","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology School of Medicine and Health Sciences The George Washington University  Washington DC USA"},{"name":"Department of Physical Education Chonbuk National University  Jeonju South 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