{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:23:55Z","timestamp":1776439435512,"version":"3.51.2"},"reference-count":50,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GS\u201082 Graduate School of Systemic Neurosciences GSN"],"award-info":[{"award-number":["GS\u201082 Graduate School of Systemic Neurosciences GSN"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KO2207\/3\u20101"],"award-info":[{"award-number":["KO2207\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB870\/2 A10"],"award-info":[{"award-number":["SFB870\/2 A10"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Ongoing, moderate noise exposure does not instantly damage the auditory system but may cause lasting deficits, such as elevated thresholds and accelerated ageing of the auditory system.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The neuromodulatory peptide urocortin\u20103 (UCN3) is involved in the body's recovery from a stress response, and is also expressed in the cochlea and the auditory brainstem.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Lack of UCN3 facilitates age\u2010induced hearing loss and causes permanently elevated auditory thresholds following a single 2\u00a0h noise exposure at moderate intensities.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Outer hair cell function in mice lacking UCN3 is unaffected, so that the observed auditory deficits are most likely due to inner hair cell function or central mechanisms.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Highly specific, rather than ubiquitous, expression of UCN3 in the brain renders it a promising candidate for designing drugs to ameliorate stress\u2010related auditory deficits, including recovery from acoustic trauma.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Environmental acoustic noise is omnipresent in our modern society, with sound levels that are considered non\u2010damaging still causing long\u2010lasting or permanent changes in the auditory system. The small neuromodulatory peptide urocortin\u20103 (UCN3) is the endogenous ligand for corticotropin\u2010releasing factor receptor type 2 and together they are known to play an important role in stress recovery. UCN3 expression has been observed in the auditory brainstem, but its role remains unclear. Here we describe the detailed distribution of UCN3 expression in the murine auditory brainstem and provide evidence that UCN3 is expressed in the synaptic region of inner hair cells in the cochlea. We also show that mice with deficient UCN3 signalling experience premature ageing of the auditory system starting at an age of 4.7\u00a0months with significantly elevated thresholds of auditory brainstem responses (ABRs) compared to age\u2010matched wild\u2010type mice. Following a single, 2\u00a0h exposure to moderate (84 or 94\u00a0dB SPL) noise, UCN3\u2010deficient mice exhibited significantly larger shifts in ABR thresholds combined with maladaptive recovery. In wild\u2010type mice, the same noise exposure did not cause lasting changes to auditory thresholds. The presence of UCN3\u2010expressing neurons throughout the auditory brainstem and the predisposition to hearing loss caused by preventing its normal expression suggests UCN3 as an important neuromodulatory peptide in the auditory system's response to loud sounds.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp278132","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T13:07:40Z","timestamp":1562245660000},"page":"4341-4355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise\u2010induced threshold shift"],"prefix":"10.1113","volume":"597","author":[{"given":"Matthew J.","family":"Fischl","sequence":"first","affiliation":[{"name":"Department of Biology II Division Neurobiology Ludwig\u2010Maximilians\u2010University  Munich 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