{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:50:18Z","timestamp":1792511418299,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u00a006637"],"award-info":[{"award-number":["RGPIN\u00a006637"]}],"id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["20150821\u201001"],"award-info":[{"award-number":["20150821\u201001"]}],"id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>In an anaesthetised animal model, independent stimulation of baroreceptors in the pulmonary artery elicits reflex sympathoexcitation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In humans, pulmonary arterial pressure is positively related to basal muscle sympathetic nerve activity (MSNA) under conditions where elevated pulmonary pressure is evident (e.g. high altitude); however, a causal link is not established.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Using a novel experimental approach, we demonstrate that reducing pulmonary arterial pressure lowers basal MSNA in healthy humans.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This response is distinct from the negative feedback reflex mediated by aortic and carotid sinus baroreceptors when systemic arterial pressure is lowered.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Afferent input from pulmonary arterial baroreceptors may contribute to sympathetic neural activation in healthy lowland natives exposed to high altitude.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      In animal models, distension of baroreceptors located in the pulmonary artery induces a reflex increase in sympathetic outflow; however, this has not been examined in humans. Therefore, we investigated whether reductions in pulmonary arterial pressure influenced sympathetic outflow and baroreflex control of muscle sympathetic nerve activity (MSNA). Healthy lowlanders (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013; 5 females) were studied 4\u20138\u00a0days following arrival at high altitude (4383\u00a0m; Cerro de Pasco, Peru), a setting that increases both pulmonary arterial pressure and sympathetic outflow. MSNA (microneurography) and blood pressure (BP; photoplethysmography) were measured continuously during ambient air breathing (Amb) and a 6\u00a0min inhalation of the vasodilator nitric oxide (iNO; 40\u00a0ppm in 21% O\n                      <jats:sub>2<\/jats:sub>\n                      ), to selectively lower pulmonary arterial pressure. A modified Oxford test was performed under both conditions. Pulmonary artery systolic pressure (PASP) was determined using Doppler echocardiography. iNO reduced PASP (24\u00a0\u00b1\u00a03\n                      <jats:italic>vs<\/jats:italic>\n                      . 32\u00a0\u00b1\u00a05\u00a0mmHg;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) compared to Amb, with a similar reduction in MSNA total activity (1369\u00a0\u00b1\u00a0576 to 994\u00a0\u00b1\u00a0474\u00a0a.u\u00a0min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01). iNO also reduced the MSNA operating point (burst incidence; 39\u00a0\u00b1\u00a016 to 33\u00a0\u00b1\u00a017 bursts\u00b7100\u00a0Hb\n                      <jats:sup>\u22121<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01) and diastolic operating pressure (82\u00a0\u00b1\u00a08 to 80\u00a0\u00b1\u00a08\u00a0mmHg;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) compared to Amb, without changing heart rate (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.6) or vascular\u2013sympathetic baroreflex gain (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.85). In conclusion, unloading of pulmonary arterial baroreceptors reduced basal sympathetic outflow to the skeletal muscle vasculature and reset vascular\u2013sympathetic baroreflex control of MSNA downward and leftward in healthy humans at high altitude. These data suggest the existence of a lesser\u2010known reflex input involved in sympathetic activation in humans.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp278731","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T12:52:49Z","timestamp":1579870369000},"page":"955-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Evidence for a physiological role of pulmonary arterial baroreceptors in sympathetic neural activation in healthy humans"],"prefix":"10.1113","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-6561","authenticated-orcid":false,"given":"Lydia L.","family":"Simpson","sequence":"first","affiliation":[{"name":"Extremes Research Group School of Sport Health and Exercise Sciences Bangor University  Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"Meah","sequence":"additional","affiliation":[{"name":"Neurovascular Health Laboratory Faculty of Kinesiology, Sport, and Recreation University of Alberta  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Steele","sequence":"additional","affiliation":[{"name":"Neurovascular Health Laboratory Faculty of Kinesiology, Sport, and Recreation University of Alberta  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-8085","authenticated-orcid":false,"given":"Suman","family":"Thapamagar","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care School of Medicine Loma Linda University  Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Gasho","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care School of Medicine Loma Linda University  Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Anholm","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care School of Medicine Loma Linda University  Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee L.","family":"Drane","sequence":"additional","affiliation":[{"name":"Cardiff School of Sport and Health Sciences Cardiff Metropolitan University  Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-135X","authenticated-orcid":false,"given":"Tony G.","family":"Dawkins","sequence":"additional","affiliation":[{"name":"Cardiff School of Sport and Health Sciences Cardiff Metropolitan University  Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Busch","sequence":"additional","affiliation":[{"name":"Neurovascular Health Laboratory Faculty of Kinesiology, Sport, and Recreation University of Alberta  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-9546","authenticated-orcid":false,"given":"Samuel J.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Extremes Research Group School of Sport Health and Exercise Sciences Bangor University  Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-7966","authenticated-orcid":false,"given":"Justin S.","family":"Lawley","sequence":"additional","affiliation":[{"name":"Department of Sport Science Division of Physiology University of Innsbruck  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-339X","authenticated-orcid":false,"given":"Michael M.","family":"Tymko","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health University of British Columbia Okanagan  Kelowna 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