{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:02:44Z","timestamp":1789545764257,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["F11\u201002423"],"award-info":[{"award-number":["F11\u201002423"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"Key points<\/jats:title>\nAerobic exercise elicits increases in cerebral blood flow (CBF), as well as core body temperature; however, the isolated influence of temperature on CBF regulation during exercise has not been investigated<\/jats:p><\/jats:list-item>\nThe present study assessed CBF regulation and neurovascular coupling during submaximal cycling exercise and temperature\u2010matched passive heat stress during isocapnia (i.e. end\u2010tidal was held constant)<\/jats:p><\/jats:list-item>\nSubmaximal cycling exercise and temperature\u2010matched passive heat stress provoked \u223c16% increases in vertebral artery blood flow, independent of changes in end\u2010tidal and blood pressure<\/jats:p><\/jats:list-item>\nExternal carotid artery blood flow increased by \u223c43% during both exercise and passive heat stress, with no change in internal carotid artery blood flow<\/jats:p><\/jats:list-item>\nNeurovascular coupling (i.e. the relationship between local increases in cerebral metabolism and appropriately matched increases in regional cerebral blood flow) is preserved during both exercise and temperature\u2010matched passive heat stress<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>Abstract<\/jats:title>Acute moderate\u2010intensity exercise increases core temperature (T<\/jats:italic>c<\/jats:sub>; +0.7\u20100.8\u00b0C); however, such exercise increases cerebral blood flow (CBF; +10\u201020%) mediated via small elevations in arterial and metabolism. The present study aimed to isolate the role of T<\/jats:italic>c<\/jats:sub> from on CBF regulation during submaximal exercise. Healthy adults (n<\/jats:italic>\u00a0=\u00a011; 10 males\/one female; 26\u00a0\u00b1\u00a04 years) participated in two interventions each separated by \u226548\u00a0h: (i) 60\u00a0min of semi\u2010recumbent cycling (EX; 50% workload max) and (ii) 75\u00a0min of passive heat stress (HS; 49\u00b0C water\u2010perfused suit) to match the exercise\u2010induced increases in T<\/jats:italic>c<\/jats:sub> (EX: \u03940.75\u00a0\u00b1\u00a00.33\u00b0C vs<\/jats:italic>. HS: \u03940.77\u00a0\u00b1\u00a00.33\u00b0C, P<\/jats:italic>\u00a0=\u00a00.855). Blood flow (Q<\/jats:italic>) in the internal and external carotid arteries (ICA and ECA, respectively) and vertebral artery (VA) (Duplex ultrasound) was measured. End\u2010tidal and were effectively clamped to resting values within each condition. The Q<\/jats:italic>ICA<\/jats:sub> was unchanged with EX and HS interventions (P<\/jats:italic>\u00a0=\u00a00.665), consistent with the unchanged end\u2010tidal (P<\/jats:italic>\u00a0=\u00a00.327); whereas, Q<\/jats:italic>VA<\/jats:sub> was higher throughout both EX and HS (EX: \u039416\u00a0\u00b1\u00a021% vs<\/jats:italic>. HS: \u039416\u00a0\u00b1\u00a023%, time effect: P<\/jats:italic>\u00a0=\u00a00.006) with no between condition differences (P<\/jats:italic>\u00a0=\u00a00.785). These increases in Q<\/jats:italic>VA<\/jats:sub> contributed to higher global CBF throughout both EX and HS (EX: \u039412\u00a0\u00b1\u00a020%\u00a0vs<\/jats:italic>. HS: \u039414\u00a0\u00b1\u00a014%, time effect: P<\/jats:italic>\u00a0=\u00a00.029; condition effect: P<\/jats:italic>\u00a0=\u00a00.869). The Q<\/jats:italic>ECA<\/jats:sub> increased throughout both EX and HS (EX: \u039442\u00a0\u00b1\u00a058% vs<\/jats:italic>. HS: \u039453\u00a0\u00b1\u00a028%, time effect: P<\/jats:italic>\u00a0<\u00a00.001; condition effect: P<\/jats:italic>\u00a0=\u00a00.628). Including blood pressure as a covariate did not alter these CBF findings (all P<\/jats:italic>\u00a0>\u00a00.05). Overall, these data provide new evidence for temperature\u2010mediated elevations in posterior CBF during exercise that are independent of changes in and blood pressure.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp278827","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T03:55:19Z","timestamp":1578455719000},"page":"1459-1473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Evidence for temperature\u2010mediated regional increases in cerebral blood flow during exercise"],"prefix":"10.1113","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6072-7277","authenticated-orcid":false,"given":"Hannah G.","family":"Caldwell","sequence":"first","affiliation":[{"name":"Centre for Heart Lung and Vascular Health School of Health and Exercise Sciences University of British Columbia Okanagan Kelowna BC 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