{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:26:24Z","timestamp":1790634384217,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL077450"],"award-info":[{"award-number":["HL077450"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL107715"],"award-info":[{"award-number":["HL107715"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>It was unknown whether respiratory alkalosis impacts the global cerebral metabolic response as well as the cerebral pro\u2010oxidation and inflammatory response in passive hyperthermia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This study demonstrated that the cerebral metabolic rate was increased by \u223c20% with passive hyperthermia of up to +2\u00b0C oesophageal temperature, and this response was unaffected by respiratory alkalosis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Additionally, the increase in cerebral metabolism did not significantly impact the net cerebral release of oxidative and inflammatory markers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data indicate that passive heating of up to +2\u00b0C core temperature in healthy young men is not enough to confer a major oxidative and inflammatory burden on the brain, but it does markedly increase the cerebral metabolic rate, independently of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp13957-math-0001.png\" xlink:title=\"urn:x-wiley:00223751:media:tjp13957:tjp13957-math-0001\"\/>.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>There is limited information concerning the impact of arterial <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp13957-math-0002.png\" xlink:title=\"urn:x-wiley:00223751:media:tjp13957:tjp13957-math-0002\"\/>\/pH on heat\u2010induced alteration in cerebral metabolism, as well as on the cerebral oxidative\/inflammatory burden of hyperthermia. Accordingly, we sought to address two hypotheses: (1) passive hyperthermia will increase the cerebral metabolic rate of oxygen (CMRO<jats:sub>2<\/jats:sub>) consistent with a combined influence of Q10 and respiratory alkalosis; and (2) the net cerebral release of pro\u2010oxidative and pro\u2010inflammatory markers will be elevated in hyperthermia, particularly in poikilocapnic hyperthermia. Healthy young men (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) underwent passive heating until an oesophageal temperature of 2\u00b0C above resting was reached. At 0.5\u00b0C increments in core temperature, CMRO<jats:sub>2<\/jats:sub> was calculated from the product of cerebral blood flow (ultrasound) and the radial artery\u2013jugular venous oxygen content difference (cannulation). Net cerebral glucose\/lactate exchange, and biomarkers of oxidative and inflammatory stress were also measured. At +2.0\u00b0C oesophageal temperature, arterial <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp13957-math-0003.png\" xlink:title=\"urn:x-wiley:00223751:media:tjp13957:tjp13957-math-0003\"\/> was restored to normothermic values using end\u2010tidal forcing. The primary findings were: (1) while CMRO<jats:sub>2<\/jats:sub> was increased (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) by \u223c20% with hyperthermia of +1.5\u20132.0\u00b0C, this was not influenced by respiratory alkalosis, and (2) although biomarkers of pro\u2010oxidation and pro\u2010inflammation were systemically elevated in hyperthermia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), there were no differences in the trans\u2010cerebral exchange kinetics. These novel data indicate that passive heating of up to +2\u00b0C core temperature in healthy young men is not enough to confer a major oxidative and inflammatory burden on the brain, despite it markedly increasing CMRO<jats:sub>2<\/jats:sub>, irrespective of arterial pH.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp278889","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T04:58:37Z","timestamp":1578113917000},"page":"943-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cerebral metabolism, oxidation and inflammation in severe passive hyperthermia with and without respiratory alkalosis"],"prefix":"10.1113","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7910-6921","authenticated-orcid":false,"given":"Anthony R.","family":"Bain","sequence":"first","affiliation":[{"name":"Faculty of Human Kinetics University of Windsor  Windsor Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-0059","authenticated-orcid":false,"given":"Ryan L.","family":"Hoiland","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Development Center for Heart Lung and Vascular Health University of British Columbia  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6502-8069","authenticated-orcid":false,"given":"Joseph","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Brain Physics Laboratory Division of Academic Neurosurgery Department of Clinical Neurosciences Addenbrookes Hospital University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Nowak\u2010Fl\u00fcck","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Development Center for Heart Lung and Vascular Health University of British Columbia  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mypinder","family":"Sekhon","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Development Center for Heart Lung and Vascular Health University of British Columbia  Kelowna British Columbia Canada"},{"name":"Division of Critical Care Medicine and Department of Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-339X","authenticated-orcid":false,"given":"Michael M.","family":"Tymko","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Development Center for Heart Lung and Vascular Health University of British Columbia  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared J.","family":"Greiner","sequence":"additional","affiliation":[{"name":"Department of 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