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They exist as calcium\u2010impermeable (CI\u2010) and calcium\u2010permeable (CP\u2010) subtypes, the latter of which lacks the GluA2 subunit. CP\u2010AMPARs display an array of distinctive biophysical and pharmacological properties that allow them to be functionally identified. This has revealed that they play crucial roles in diverse forms of central synaptic plasticity. Here we summarise the functional hallmarks of CP\u2010AMPARs and describe how these are modified by the presence of auxiliary subunits that have emerged as pivotal regulators of AMPARs. A lasting change in the prevalence of GluA2\u2010containing AMPARs, and hence in the fraction of CP\u2010AMPARs, is a feature in many maladaptive forms of synaptic plasticity and neurological disorders. These include modifications of glutamatergic transmission induced by inflammatory pain, fear conditioning, cocaine exposure, and anoxia\u2010induced damage in neurons and glia. Furthermore, defective RNA editing of GluA2 can cause altered expression of CP\u2010AMPARs and is implicated in motor neuron damage (amyotrophic lateral sclerosis) and the proliferation of cells in malignant gliomas. A number of the players involved in CP\u2010AMPAR regulation have been identified, providing useful insight into interventions that may prevent the aberrant CP\u2010AMPAR expression. Furthermore, recent molecular and pharmacological developments, particularly the discovery of TARP subtype\u2010selective drugs, offer the exciting potential to modify some of the harmful effects of increased CP\u2010AMPAR prevalence in a brain region\u2010specific manner.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp14565-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  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