{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:03Z","timestamp":1787016123715,"version":"build-2736575974"},"reference-count":100,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32DK007664\u201028"],"award-info":[{"award-number":["5T32DK007664\u201028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30DK112563"],"award-info":[{"award-number":["F30DK112563"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32AI136404"],"award-info":[{"award-number":["F32AI136404"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T15LM007093"],"award-info":[{"award-number":["T15LM007093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010DK\u201056338"],"award-info":[{"award-number":["P30\u2010DK\u201056338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA170930"],"award-info":[{"award-number":["U01CA170930"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Enteroids are a physiologically relevant model to examine the human intestine and its functions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Previously, the measurable cytokine response of human intestinal enteroids has been limited following exposure to host or microbial pro\u2010inflammatory stimuli.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Modifications to enteroid culture conditions facilitated robust human cytokine responses to pro\u2010inflammatory stimuli.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This new human enteroid culture methodology refines the ability to study microbiome:human intestinal epithelium interactions in the laboratory.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The intestinal epithelium is the primary interface between the host, the gut microbiome and its external environment. Since the intestinal epithelium contributes to innate immunity as a first line of defence, understanding how the epithelium responds to microbial and host stimuli is an important consideration in promoting homeostasis. Human intestinal enteroids (HIEs) are primary epithelial cell cultures that can provide insights into the biology of the intestinal epithelium and innate immune responses. One potential limitation of using HIEs for innate immune studies is the relative lack of responsiveness to factors that stimulate epithelial cytokine production. We report technical refinements, including removal of extracellular antioxidants, to facilitate enhanced cytokine responses in HIEs. Using this new method, we demonstrate that HIEs have distinct cytokine profiles in response to pro\u2010inflammatory stimuli derived from host and microbial sources. Overall, we found that host\u2010derived cytokines tumour necrosis factor and interleukin\u20101\u03b1 stimulated reactive oxygen species and a large repertoire of cytokines. In contrast, microbial lipopolysaccharide, lipoteichoic acid and flagellin stimulated a limited number of cytokines and histamine did not stimulate the release of any cytokines. Importantly, HIE\u2010secreted cytokines were functionally active, as denoted by the ability of human blood\u2010derived neutrophil to migrate towards HIE supernatant containing interleukin\u20108. These findings establish that the immune responsiveness of HIEs depends on medium composition and stimuli. By refining the experimental culture medium and creating an environment conducive to epithelial cytokine responses by human enteroids, HIEs can facilitate exploration of many experimental questions pertaining to the role of the intestinal epithelium in innate immunity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp279423","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T17:29:57Z","timestamp":1589909397000},"page":"3085-3105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Enhancing responsiveness of human jejunal enteroids to host and microbial stimuli"],"prefix":"10.1113","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-5543","authenticated-orcid":false,"given":"Wenly","family":"Ruan","sequence":"first","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston Texas USA"},{"name":"Section of Gastroenterology, Hepatology, and Nutrition Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda A.","family":"Engevik","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L.","family":"Chang\u2010Graham","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology &amp; Microbiology Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-0021","authenticated-orcid":false,"given":"Heather A.","family":"Danhof","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology &amp; Microbiology Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Goodwin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston Texas USA"},{"name":"Section of Gastroenterology, Hepatology, and Nutrition Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-1875","authenticated-orcid":false,"given":"Kristen A.","family":"Engevik","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology &amp; Microbiology Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongcheng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6814-6514","authenticated-orcid":false,"given":"Anne","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara C. Di","family":"Rienzi","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology &amp; Microbiology Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Venable","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Britton","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology &amp; Microbiology Baylor College of Medicine Houston TX USA"},{"name":"Alkek Center for Metagenomics and Microbiome Research Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hyser","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology &amp; Microbiology Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-4385","authenticated-orcid":false,"given":"James","family":"Versalovic","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2463"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-325225"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.34.20545"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-172"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.150888"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13428"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3174"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2017.12.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2017.12.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2017.12.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2019.04.010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072900"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187880"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01313-07"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.9.1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0437-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2912539"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74429-9"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2008.0027"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.BAD-0012-2016"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf5211"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.24"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.04.008"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.1.90"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90436-0"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00261-13"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.052555"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(02)00311-2"},{"key":"e_1_2_6_31_1","first-page":"1342","article-title":"Mucosal interleukin\u20108 is involved in neutrophil migration and binding to extracellular matrix in inflammatory bowel disease","volume":"92","author":"Ina K","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0397-0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712799828283"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1993.tb01643.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.041"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6522"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2008.40.2.167"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522193112"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.19"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.04.021"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.08.017"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.291-ce1184.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15993.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80038-2"},{"key":"e_1_2_6_45_1","first-page":"620","article-title":"Mast cell: a multi\u2010functional master cell","volume":"6","author":"Krystel\u2010Whittemore M","year":"2015","journal-title":"Front Immunol"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01830"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3230"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113519171"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.7603\/s40681-015-0005-x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-009-0751-8"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.004"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.106"},{"key":"e_1_2_6_53_1","first-page":"997","article-title":"Expression of interleukin\u20108 gene in inflammatory bowel disease is related to the histological grade of active inflammation","volume":"144","author":"Mazzucchelli L","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1038"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5149"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.10.2864-2870.1993"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03034.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270722"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-01540-y"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617722903"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090849"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.03.010"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-008-0120-9"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200401116"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700316"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-11-0279"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.62"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.03.003"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-8-2-233"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02531-10"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1089\/107999003321455507"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081887"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200115060-00008"},{"key":"e_1_2_6_74_1","doi-asserted-by":"crossref","first-page":"1049.1046","DOI":"10.1096\/fasebj.31.1_supplement.1049.6","article-title":"The Differential Response of Human Epithelial Derived Colonic Organoids to TLR Agonists","volume":"31","author":"Samuel G","year":"2017","journal-title":"FASEB J"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00065"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102061200"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.07.050"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07935"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01930-15"},{"key":"e_1_2_6_80_1","first-page":"85","article-title":"Colonic epithelial cell lines as a source of interleukin\u20108: stimulation by inflammatory cytokines and bacterial lipopolysaccharide","volume":"81","author":"Schuerer\u2010Maly CC","year":"1994","journal-title":"Immunology"},{"key":"e_1_2_6_81_1","first-page":"21396","article-title":"The effect of healing phenotype\u2010inducing cytokine formulations within soft hydrogels on encapsulated monocytes and incoming immune cells","volume":"9","author":"\u0160\u010digalkov\u00e1 I","year":"2019","journal-title":"Royal Society of Chemistry Advances"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-121"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9020165"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-010-1321-9"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2019.11.008"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)92905-4"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.000687"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20296"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2012.02628.x"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112127"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1159\/000237162"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031951"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65128-0"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306651"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.2.208"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm5120118"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802217"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.635995"},{"key":"e_1_2_6_99_1","first-page":"1399","article-title":"CXC chemokines and their receptors: a case for a significant biological role in cutaneous wound healing","volume":"23","author":"Zaja\u2010Milatovic S","year":"2008","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40348-016-0041-y"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.04.022"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FJP279423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP279423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP279423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP279423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:15:13Z","timestamp":1722892513000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP279423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,13]]},"references-count":100,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1113\/JP279423"],"URL":"https:\/\/doi.org\/10.1113\/jp279423","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,13]]},"assertion":[{"value":"2019-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}