{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:03:15Z","timestamp":1791442995237,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K021133\/1"],"award-info":[{"award-number":["MR\/K021133\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Placental pathological abnormalities are more frequently observed in complicated pregnancies than in healthy pregnancies.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Infiltration of CD8<jats:sup>+<\/jats:sup> T\u2010cells into the placental villous tissue occurred in both fetal growth restriction and pre\u2010eclampsia, whereas CD79\u03b1<jats:sup>+<\/jats:sup> B\u2010cell infiltration was only apparent with reduced fetal growth.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Vascularization, fibrin depositions, macrophage and neutrophil infiltration in the placenta did not differ between healthy and complicated pregnancies.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Fetal growth restriction (FGR) and pre\u2010eclampsia are severe, adverse pregnancy outcomes. Alterations in placental histology are frequently reported in these pregnancy complications and are often based upon scoring by pathologists. However, many alterations are also observed in placenta from uncomplicated pregnancies. Moreover, knowledge of disease state may bias assessment. We sought to perform an objective comparison of placental microscopic appearance in normal and complicated pregnancies. Placental villous tissue (<jats:italic>n<\/jats:italic>\u00a0=\u00a0823) and edge biopsies (<jats:italic>n<\/jats:italic>\u00a0=\u00a0488) from 871 individual, singleton pregnancies were collected after delivery. Cases of small\u2010for\u2010gestational age (SGA) or pre\u2010eclampsia were matched with healthy controls. A subset of the SGA cases displayed signs of FGR. Cases of preterm delivery were also included. Tissue sections were stained with haematoxylin and eosin or antibodies for CD8, CD14, CD31, CD79\u03b1 and elastase. Images were scored by two experienced pathologists for pathological features or analysed by image analysis and stereology. Analyses were performed blind to case\u2013control status and gestational age. Volume fraction of T\u2010cells increased in placentas from pregnancies complicated by pre\u2010eclampsia (adjusted odds ratio (aOR) 1.46, 95% CI: 1.12\u20131.90) and FGR (aOR 1.64, 95% CI: 1.11\u20132.43), whereas B\u2010cells only increased in FGR (aOR 1.65, 95% CI: 1.05\u20132.60). Pathological abnormalities in villous tissue were reported in 21.4% (88\/411) of complicated pregnancies and 14.3% (52\/363) of controls (OR 1.62, 95% CI: 1.12\u20132.37). There were no differences in the fractions of endothelial cells, fibrin deposition, macrophages and neutrophils when comparing normal and complicated pregnancies. In conclusion, FGR and pre\u2010eclampsia are associated with T\u2010cell infiltration of the placenta and placental pathological abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp279532","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T17:35:25Z","timestamp":1599240925000},"page":"5555-5571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Abnormal placental CD8<sup>+<\/sup> T\u2010cell infiltration is a feature of fetal growth restriction and pre\u2010eclampsia"],"prefix":"10.1113","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-065X","authenticated-orcid":false,"given":"Susanne","family":"Lager","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of Cambridge and NIHR Cambridge Biomedical Research Centre  Cambridge UK"},{"name":"Centre for Trophoblast Research Department of Physiology Development and Neuroscience University of Cambridge  UK"},{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-1105","authenticated-orcid":false,"given":"Ulla","family":"Sovio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of Cambridge and NIHR Cambridge Biomedical Research Centre  Cambridge UK"},{"name":"Centre for Trophoblast Research Department of Physiology Development and Neuroscience University of Cambridge  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Eddershaw","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of Cambridge and NIHR Cambridge Biomedical Research Centre  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaretha W.","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of Cambridge and NIHR Cambridge Biomedical Research Centre  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-0111","authenticated-orcid":false,"given":"Cansu","family":"Yazar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of Cambridge and NIHR Cambridge Biomedical Research Centre  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6142-4443","authenticated-orcid":false,"given":"Emma","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of Cambridge and NIHR Cambridge Biomedical Research Centre  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Happerfield","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pathology Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora A.","family":"Jessop","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pathology Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5348-9063","authenticated-orcid":false,"given":"Neil J.","family":"Sebire","sequence":"additional","affiliation":[{"name":"Departments of Paediatric Pathology Camelia Botnar Laboratories Great Ormond Street Hospital and Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-4890","authenticated-orcid":false,"given":"D. 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