{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:02:45Z","timestamp":1790712165686,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"\n Key points<\/jats:title>\n \n \n \n The vagus nerve is the largest cranial nerve and innervates many structures in the neck, thorax and abdomen.<\/jats:p>\n <\/jats:list-item>\n \n Although single\u2010unit recordings from the vagus nerve have been performed in experimental animals for several decades, no recordings have ever been made from the human vagus nerve.<\/jats:p>\n <\/jats:list-item>\n \n The vagus nerve is routinely stimulated clinically, yet we know little of its physiology in humans.<\/jats:p>\n <\/jats:list-item>\n \n We describe the methodology and provide preliminary results of the first intraneural single\u2010unit recordings from the cervical vagus in awake humans, using tungsten microelectrodes inserted into the nerve through ultrasound guidance.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Abstract<\/jats:title>\n Intraneural microelectrodes have been used extensively to record from single somatosensory axons supplying muscle, tendons, joints and skin, as well as to record from postganglionic sympathetic axons supplying muscle and skin, in accessible peripheral nerves in awake humans. However, the vagus nerve has never been targeted, probably because of its close proximity to the carotid artery and jugular vein in the neck. Here, we report the first unitary recordings from the human cervical vagus nerve, obtained using ultrasound\u2010guided insertion of tungsten microelectrodes into fascicles of the nerve. We identified tonically\u2010active neurones in which firing rates were inversely related to heart rate (and directly related to the cardiac interval), which we classified as putative preganglionic parasympathetic axons directed to the sinoatrial node of the heart. We also recorded from tonically\u2010active presumed sensory axons from the airways and presumed motor axons to the larynx. This new methodology opens exciting new opportunities for studying the physiology of the human vagus nerve in health and disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1113\/jp280077","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T08:43:36Z","timestamp":1592210616000},"page":"3569-3576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["In vivo<\/i>\n recordings from the human vagus nerve using ultrasound\u2010guided microneurography"],"prefix":"10.1113","volume":"598","author":[{"given":"Matteo M.","family":"Ottaviani","sequence":"first","affiliation":[{"name":"Scuolo Superiore Sant'Anna Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Wright","sequence":"additional","affiliation":[{"name":"Baker Heart and Diabetes Institute Melbourne VIC 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