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The commonly used angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could affect SARS\u2010CoV\u20102 infectivity and may alter COVID\u201019 disease progression by altering ACE2 expression. Current evidence of ACEI\/ARB\u2010ACE2 interaction as well as the effects of ACEIs\/ARBs on viral\u2010associated acute lung injury is summarized and discussed in this review. 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