{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:02Z","timestamp":1787016182111,"version":"build-2736575974"},"reference-count":200,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["SFI\/12\/RC\/2273 P2"],"award-info":[{"award-number":["SFI\/12\/RC\/2273 P2"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is clear evidence of physiological effects of the gut microbiota on whole\u2010body function in health and disease. Microbiota\u2013gut\u2013brain axis signalling is recognised as a key player in behavioural disorders such as depression and anxiety. Recent evidence suggests that the gut microbiota affects neurocontrol networks responsible for homeostatic functions that are essential for life. We consider the evidence suggesting the potential for the gut microbiota to shape cardiorespiratory homeostasis. In various animal models of disease, there is an association between cardiorespiratory morbidity and perturbed gut microbiota, with strong evidence in support of a role of the gut microbiota in the control of blood pressure. Interventions that target the gut microbiota or manipulate the gut\u2013brain axis, such as short\u2010chain fatty acid supplementation, prevent hypertension in models of obstructive sleep apnoea. Emerging evidence points to a role for the microbiota\u2013gut\u2013brain axis in the control of breathing and ventilatory responsiveness, relevant to cardiorespiratory disease. There is also evidence for an association between the gut microbiota and disease severity in people with asthma and cystic fibrosis. There are many gaps in the knowledge base and an urgent need to better understand the mechanisms by which gut health and dysbiosis contribute to cardiorespiratory control. Nevertheless, there is a growing consensus that manipulation of the gut microbiota could prove an efficacious adjunctive strategy in the treatment of common cardiorespiratory diseases, which are the leading causes of morbidity and mortality.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp14254-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp280279","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T17:43:25Z","timestamp":1594489405000},"page":"4159-4179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Bugs, breathing and blood pressure: microbiota\u2013gut\u2013brain axis signalling in cardiorespiratory control in health and disease"],"prefix":"10.1113","volume":"598","author":[{"given":"Karen M.","family":"O'Connor","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine, College of Medicine &amp; Health University College Cork  Cork Ireland"},{"name":"Department of Anatomy &amp; Neuroscience, School of Medicine, College of Medicine &amp; Health University College Cork  Cork Ireland"},{"name":"APC Microbiome Ireland University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-2904","authenticated-orcid":false,"given":"Eric F.","family":"Lucking","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, College of Medicine &amp; Health University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-2723","authenticated-orcid":false,"given":"John F.","family":"Cryan","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Neuroscience, School of Medicine, College of Medicine &amp; Health University College Cork  Cork Ireland"},{"name":"APC Microbiome Ireland University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-1153","authenticated-orcid":false,"given":"Ken D.","family":"O'Halloran","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, College of Medicine &amp; Health University College Cork  Cork Ireland"},{"name":"APC Microbiome Ireland University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1046-12.2013"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12253"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00081.2016"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.058"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00465"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2017.05.019"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab2271"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09944"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121189"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2019.03.004"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2012.11.001"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.031"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303035"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036652"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.011"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21864"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2016.10.024"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.04.052"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01796.x"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/257139"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(00)00215-0"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108067"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0425-1"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.05.002"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009759"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102999108"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00044"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.01.004"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-017-0968-8"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.12.031"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aambs.2015.02.001"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.128"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.3.329"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127119"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.77"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.02.013"},{"key":"e_1_2_2_38_1","first-page":"1","article-title":"Afferent vagal C fibre innervation of the lungs and airways and its functional significance","volume":"99","author":"Coleridge JC","year":"1984","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.04.014"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01664.x"},{"key":"e_1_2_2_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2018"},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30356-4"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184336"},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0157-3"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2005.09.002"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07255"},{"key":"e_1_2_2_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.65"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.04.004"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.03.009"},{"key":"e_1_2_2_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.08.005"},{"key":"e_1_2_2_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010529108"},{"key":"e_1_2_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.09.007"},{"key":"e_1_2_2_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00694"},{"key":"e_1_2_2_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.06.007"},{"key":"e_1_2_2_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06672"},{"key":"e_1_2_2_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-4584-1_48"},{"key":"e_1_2_2_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00146"},{"key":"e_1_2_2_58_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.43.030181.001005"},{"key":"e_1_2_2_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4030"},{"key":"e_1_2_2_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.20.5.612"},{"key":"e_1_2_2_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.6.555"},{"key":"e_1_2_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2017.03.001"},{"key":"e_1_2_2_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09252-4"},{"key":"e_1_2_2_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1214-12.2013"},{"key":"e_1_2_2_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.008"},{"key":"e_1_2_2_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11695"},{"key":"e_1_2_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53825-3.00008-5"},{"key":"e_1_2_2_68_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00003309"},{"key":"e_1_2_2_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.117176"},{"key":"e_1_2_2_70_1","first-page":"920","article-title":"Epidemiological aspects of obstructive sleep apnea","volume":"7","author":"Garvey JF","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_2_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2003.08.002"},{"key":"e_1_2_2_72_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.052894"},{"key":"e_1_2_2_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0464-9"},{"key":"e_1_2_2_74_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34245"},{"key":"e_1_2_2_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(00)00219-8"},{"key":"e_1_2_2_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.08.009"},{"key":"e_1_2_2_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.06.002"},{"key":"e_1_2_2_78_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.095968"},{"key":"e_1_2_2_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00094"},{"key":"e_1_2_2_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.01.014"},{"key":"e_1_2_2_81_1","first-page":"233","article-title":"Clinical immunology effect of orally administered probiotic strains Lactobacillus and Bifidobacterium in children with atopic asthma","volume":"35","author":"Gutkowski P","year":"2011","journal-title":"Central Eur J Immunol"},{"key":"e_1_2_2_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1902"},{"key":"e_1_2_2_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140004"},{"key":"e_1_2_2_84_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316434"},{"key":"e_1_2_2_85_1","first-page":"47","article-title":"Checks and balances in neuromodulation","volume":"4","author":"Harris\u2010Warrick RM","year":"2010","journal-title":"Front Behav Neurosci"},{"key":"e_1_2_2_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008578"},{"key":"e_1_2_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.10.003"},{"key":"e_1_2_2_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00618.x"},{"key":"e_1_2_2_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.04.003"},{"key":"e_1_2_2_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.024"},{"key":"e_1_2_2_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.02.010"},{"key":"e_1_2_2_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.044"},{"key":"e_1_2_2_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00775-y"},{"key":"e_1_2_2_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-017-0735-0"},{"key":"e_1_2_2_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep037"},{"key":"e_1_2_2_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2012.07.001"},{"key":"e_1_2_2_97_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP086716"},{"key":"e_1_2_2_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00884.2007"},{"key":"e_1_2_2_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002494"},{"key":"e_1_2_2_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2407-x"},{"key":"e_1_2_2_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.07.019"},{"key":"e_1_2_2_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00392"},{"key":"e_1_2_2_103_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151345"},{"key":"e_1_2_2_104_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20180087"},{"key":"e_1_2_2_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016088108"},{"key":"e_1_2_2_106_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319240012"},{"key":"e_1_2_2_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1287"},{"key":"e_1_2_2_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20827-x"},{"key":"e_1_2_2_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.11.003"},{"key":"e_1_2_2_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.024"},{"key":"e_1_2_2_111_1","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dsm018"},{"key":"e_1_2_2_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.4.G907"},{"key":"e_1_2_2_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0752-7"},{"key":"e_1_2_2_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2006.08.007"},{"key":"e_1_2_2_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0222-x"},{"key":"e_1_2_2_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00840"},{"key":"e_1_2_2_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.01.041"},{"key":"e_1_2_2_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061639"},{"key":"e_1_2_2_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011175"},{"key":"e_1_2_2_120_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00261"},{"key":"e_1_2_2_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.11.010"},{"key":"e_1_2_2_122_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600266"},{"key":"e_1_2_2_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003726"},{"key":"e_1_2_2_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0897-4_1"},{"key":"e_1_2_2_125_1","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.SGE_Macfarlane"},{"key":"e_1_2_2_126_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091334"},{"key":"e_1_2_2_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"e_1_2_2_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.120"},{"key":"e_1_2_2_129_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024545"},{"key":"e_1_2_2_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2538"},{"key":"e_1_2_2_131_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.10.117"},{"key":"e_1_2_2_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.06.005"},{"key":"e_1_2_2_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.10.015"},{"key":"e_1_2_2_134_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00184314"},{"key":"e_1_2_2_135_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6176"},{"key":"e_1_2_2_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4051"},{"key":"e_1_2_2_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuw069"},{"key":"e_1_2_2_138_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103740"},{"key":"e_1_2_2_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.01.040"},{"key":"e_1_2_2_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.075"},{"key":"e_1_2_2_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.03.029"},{"key":"e_1_2_2_142_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP087868"},{"key":"e_1_2_2_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2015.10.013"},{"key":"e_1_2_2_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.07.027"},{"key":"e_1_2_2_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2010-9"},{"key":"e_1_2_2_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-019-02322-y"},{"key":"e_1_2_2_147_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095476"},{"key":"e_1_2_2_148_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2824"},{"key":"e_1_2_2_149_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4768-08.2009"},{"key":"e_1_2_2_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35405"},{"key":"e_1_2_2_151_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00809.2003"},{"key":"e_1_2_2_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"e_1_2_2_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110033"},{"key":"e_1_2_2_154_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00292.2001"},{"key":"e_1_2_2_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2009.35"},{"key":"e_1_2_2_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900616"},{"key":"e_1_2_2_157_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.043224-0"},{"key":"e_1_2_2_158_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309006"},{"key":"e_1_2_2_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.09.002"},{"key":"e_1_2_2_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-018-1506-2"},{"key":"e_1_2_2_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.013"},{"key":"e_1_2_2_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1560-1"},{"key":"e_1_2_2_163_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12734"},{"key":"e_1_2_2_164_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900063"},{"key":"e_1_2_2_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.11.004"},{"key":"e_1_2_2_166_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241165"},{"key":"e_1_2_2_167_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00432"},{"key":"e_1_2_2_168_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198506000-00005"},{"key":"e_1_2_2_169_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040413"},{"key":"e_1_2_2_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.016"},{"key":"e_1_2_2_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0617-x"},{"key":"e_1_2_2_172_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00147"},{"key":"e_1_2_2_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12109"},{"key":"e_1_2_2_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2016.06.011"},{"key":"e_1_2_2_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.03.015"},{"key":"e_1_2_2_176_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063388"},{"key":"e_1_2_2_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24448"},{"key":"e_1_2_2_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2018.09.511"},{"key":"e_1_2_2_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8320"},{"key":"e_1_2_2_180_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1019"},{"key":"e_1_2_2_181_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.36.261"},{"key":"e_1_2_2_182_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00231"},{"key":"e_1_2_2_183_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00020-18"},{"key":"e_1_2_2_184_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144854"},{"key":"e_1_2_2_185_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP276431"},{"key":"e_1_2_2_186_1","article-title":"Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy","volume":"128","author":"Nimwegen FA","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_2_187_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz152"},{"key":"e_1_2_2_188_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208171"},{"key":"e_1_2_2_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-014-1583-0"},{"key":"e_1_2_2_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.08.002"},{"key":"e_1_2_2_191_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i18.2180"},{"key":"e_1_2_2_192_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-018-1257-x"},{"key":"e_1_2_2_193_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01406-2015"},{"key":"e_1_2_2_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10003"},{"key":"e_1_2_2_195_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2007.03400.x"},{"key":"e_1_2_2_196_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201801-0119OC"},{"key":"e_1_2_2_197_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5068"},{"key":"e_1_2_2_198_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7336"},{"key":"e_1_2_2_199_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00381"},{"key":"e_1_2_2_200_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05315"},{"key":"e_1_2_2_201_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3644-12.2014"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FJP280279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP280279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP280279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP280279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:26:12Z","timestamp":1693344372000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP280279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":200,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1113\/JP280279"],"URL":"https:\/\/doi.org\/10.1113\/jp280279","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,21]]},"assertion":[{"value":"2020-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}