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Weakness extends to the respiratory musculature, and cardiorespiratory failure is the leading cause of death in men with DMD. Intermittent hypoxia has emerged as a potential therapy to counteract ventilatory insufficiency by eliciting long\u2010term facilitation of breathing. Mechanisms of sensory and motor facilitation of breathing have been well delineated in animal models. Various paradigms of intermittent hypoxia have been designed and implemented in human trials culminating in clinical trials in people with spinal cord injury and amyotrophic lateral sclerosis. Application of therapeutic intermittent hypoxia to DMD is considered together with discussion of the potential barriers to progression owing to the complexity of this devastating disease. Notwithstanding the considerable challenges and potential pitfalls of intermittent hypoxia\u2010based therapies for DMD, we suggest it is incumbent on the research community to explore the potential benefits in pre\u2010clinical models. Intermittent hypoxia paradigms should be implemented to explore the proclivity to express respiratory plasticity with the longer\u2010term aim of preserving and potentiating ventilation in pre\u2010clinical models and people with DMD.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16139-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp280280","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T21:02:16Z","timestamp":1717534936000},"page":"3255-3272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["BREATHE DMD: boosting respiratory efficacy after therapeutic hypoxic episodes in Duchenne muscular dystrophy"],"prefix":"10.1113","volume":"602","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-9670","authenticated-orcid":false,"given":"Se\u00e1n C.","family":"\u00d3 Murch\u00fa","sequence":"first","affiliation":[{"name":"Department of Physiology University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-1153","authenticated-orcid":false,"given":"Ken D.","family":"O'Halloran","sequence":"additional","affiliation":[{"name":"Department of Physiology University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103387"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)80018-X"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.11.005"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau1549"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18944"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP283700"},{"key":"e_1_2_2_8_1","first-page":"709","article-title":"Long\u2010term facilitation of ventilation in humans during NREM sleep","volume":"21","author":"Babcock M. 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