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The present study aimed to determine the brain\u2010mediated mechanisms involved in the thermoregulatory changes observed during lipopolysaccharide (LPS)\u2010induced systemic inflammation (SI; at a septic\u2010like model) in spontaneously hypertensive rats (SHR). We combined Tb and skin temperature (Tsk) analysis, assessment of prostaglandin (PG) E<jats:sub>2<\/jats:sub> levels (the proximal mediator of fever) in the anteroventral region of the hypothalamus (AVPO; an important site for Tb control), oxygen consumption analysis, cardiovascular recordings, assays of inflammatory markers, and evaluation of oxidative stress in the plasma and brain of male Wistar rats and SHR that had received LPS (1.5\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) or saline. LPS induced hypothermia followed by fever in Wistar rats, whereas, in SHR, a maintained hypothermia without fever were observed. These thermoregulatory responses were associated with an increased heat loss in SHR compared to Wistar rats. We measured LPS\u2010induced increased PGE<jats:sub>2<\/jats:sub> levels in the AVPO in Wistar rats, but not in SHR. The LPS\u2010induced drop in blood pressure was higher in SHR than in Wistar rats. Furthermore, LPS\u2010induced plasma and brain [regions involved in autonomic control: nucleus tractus solitarius (NTS) and rostral ventrolateral medulla (RVLM)] cytokine surges were blunted, whereas oxidative stress was higher in SHR. LPS\u2010induced SI leads to blunted cytokine surges both systemically (plasma) and centrally (NTS and RVLM) and reduced hypothalamic PGE<jats:sub>2<\/jats:sub> production, which are all associated with increased hypothermia mediated by increased heat loss, but not by heat production, in SHR.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp280321","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T15:19:49Z","timestamp":1596554389000},"page":"4663-4680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased lipopolysaccharide\u2010induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE<sub>2<\/sub> production and increased heat loss"],"prefix":"10.1113","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-4853","authenticated-orcid":false,"given":"Mateus R.","family":"Amorim","sequence":"first","affiliation":[{"name":"Dental School of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Johns Hopkins University, School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-247X","authenticated-orcid":false,"given":"Diego A.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Dental School of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna M.","family":"Santos","sequence":"additional","affiliation":[{"name":"Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo D.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"},{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatas E.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sports of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fania L.","family":"de Deus","sequence":"additional","affiliation":[{"name":"Dental School of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"},{"name":"The Solomon H. 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