{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:53:37Z","timestamp":1787889217253,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Ventrolateral thalamus (VL) integrates information from cerebellar nuclei and motor cortical layer VI.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Inputs from the cerebellar nuclei evoke large\u2010amplitude responses that depress upon repetitive stimulation while layer VI inputs from motor cortex induce small\u2010amplitude facilitating responses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We report that the spiking of VL neurons can be determined by the thalamic membrane potential, the frequency of cerebellar inputs and the duration of pauses after cerebellar high frequency stimulation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Inputs from motor cortical layer VI shift the VL membrane potential and modulate the VL spike output in response to cerebellar stimulation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>\u00a0These results help us to decipher how the cerebellar output is integrated in VL and modulated by motor cortical input.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Orchestrating complex movements requires well\u2010timed interaction of cerebellar, thalamic and cerebral structures, but the mechanisms underlying the integration of cerebro\u2010cerebellar information in motor thalamus remain largely unknown. Here we investigated how excitatory inputs from cerebellar nuclei (CN) and primary motor cortex layer VI (M1\u2010L6) neurons may regulate the activity of neurons in the mouse ventrolateral (VL) thalamus. Using dual\u2010optical stimulation of the CN and M1\u2010L6 axons and <jats:italic>in vitro<\/jats:italic> whole\u2010cell recordings of the responses in VL neurons, we studied the individual responses as well as the effects of combined CN and M1\u2010L6 stimulation. Whereas CN inputs evoked large\u2010amplitude responses that were depressed upon repetitive stimulation, M1\u2010L6 inputs elicited small\u2010amplitude responses that were facilitated upon repetitive stimulation. Moreover, pauses in CN stimuli could directly affect VL spiking probability, an effect that was modulated by VL membrane potential. When CN and M1\u2010L6 pathways were co\u2010activated, motor cortical afferents increased the thalamic spike output in response to cerebellar stimulation, indicating that CN and M1 synergistically, yet differentially, control the membrane potential and spiking pattern of VL neurons.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp280455","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T20:47:33Z","timestamp":1611607653000},"page":"2055-2073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Temporal dynamics of the cerebello\u2010cortical convergence in ventro\u2010lateral motor thalamus"],"prefix":"10.1113","volume":"599","author":[{"given":"Carmen B.","family":"Sch\u00e4fer","sequence":"first","affiliation":[{"name":"Department of Neuroscience Erasmus MC  Rotterdam 3015 AA The 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