{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:33:57Z","timestamp":1781735637919,"version":"3.54.5"},"reference-count":71,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The carotid chemoreceptor mediates the ventilatory and muscle sympathetic nerve activity (MSNA) responses to hypoxia and contributes to tonic sympathetic and respiratory drives. It is often presumed that both excitatory and inhibitory tests of chemoreflex function show congruence in the end\u2010organ responses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Ventilatory and neurocirculatory (MSNA, blood pressure and heart rate) responses to chemoreflex inhibition elicited by transient hyperoxia and to chemoreflex excitation produced by steady\u2010state eucapnic hypoxia were measured in a cohort of 82\u00a0middle\u2010aged individuals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Ventilatory and MSNA responsiveness to hyperoxia and hypoxia were not significantly correlated within individuals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It was concluded that ventilatory responses to hypoxia and hyperoxia do not predict MSNA responses and it is recommended that tests using the specific outcome of interest, i.e. MSNA or ventilation, are required.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Transient hyperoxia is recommended as a sensitive and reliable means of quantifying tonic chemoreceptor\u2010driven levels of sympathetic nervous system activity and respiratory drive.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Hypersensitivity of the carotid chemoreceptor leading to sympathetic nervous system activation and ventilatory instability has been implicated in the pathogenesis and consequences of several common clinical conditions. A variety of treatment approaches aimed at lessening chemoreceptor\u2010driven sympathetic overactivity are now under investigation; thus, the ability to quantify this outcome variable with specificity and precision is crucial. Accordingly, we measured ventilatory and neurocirculatory responses to chemoreflex inhibition elicited by transient hyperoxia and chemoreflex excitation produced by exposure to graded, steady\u2010state eucapnic hypoxia in middle\u2010aged men and women (<jats:italic>n<\/jats:italic>\u00a0=\u00a082) with continuous positive airway pressure\u2010treated obstructive sleep apnoea. Progressive, eucapnic hypoxia produced robust and highly variable increases in ventilation (+83\u00a0\u00b1\u00a059%) and muscle sympathetic nerve activity (MSNA) burst frequency (+55\u00a0\u00b1\u00a031%), whereas transient hyperoxia caused marked reductions in these variables (\u221235\u00a0\u00b1\u00a014% and \u221242\u00a0\u00b1\u00a016%, respectively). Coefficients of variation for ventilatory and MSNA burst frequency responses, indicating test\u2013retest reproducibility, were respectively 9% and 24% for hyperoxia and 35% and 28% for hypoxia. Based on statistical measures of rank correlation or even comparisons across quartiles of corresponding ventilatory and MSNA responses, we found that the magnitudes of ventilatory inhibition with hyperoxia or excitation with eucapnic hypoxia were not correlated with corresponding MSNA responses within individuals. We conclude that, in conscious, behaving humans, ventilatory sensitivities to progressive, steady\u2010state, eucapnic hypoxia and transient hyperoxia do not predict MSNA responsiveness. Our findings also support the use of transient hyperoxia as a reliable, sensitive, measure of the carotid chemoreceptor contribution to tonic sympathetic nervous system activity and respiratory drive.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp280515","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T07:02:19Z","timestamp":1596870139000},"page":"4803-4819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The need for specificity in quantifying neurocirculatory <i>vs<\/i>. respiratory effects of eucapnic hypoxia and transient hyperoxia"],"prefix":"10.1113","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-996X","authenticated-orcid":false,"given":"Bharati","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Medicine University of Illinois at Chicago  Chicago IL 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