{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:17:32Z","timestamp":1778894252571,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,27]],"date-time":"2020-12-27T00:00:00Z","timestamp":1609027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Chronic hypoxaemia is associated with intrauterine growth restriction (IUGR) and a predisposition to the development of hypertension in adult life.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>IUGR fetuses exhibit a greater reliance on \u03b1\u2010adrenergic activation for blood pressure regulation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The fetal blood pressure response to post\u2010ganglionic blockade is not different between control and IUGR fetuses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The decrease in mean arterial pressure is greater in the IUGR sheep fetus after \u03b1\u2010adrenergic receptor blockade at the level of the vasculature and this is inversely related to fetal <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp14494-math-0001.png\" xlink:title=\"urn:x-wiley:00223751:media:tjp14494:tjp14494-math-0001\"\/>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The increased reliance that the IUGR fetus has on \u03b1\u2010adrenergic activation for maintenance of mean arterial pressure is not a result of increased post\u2010ganglionic sympathetic activation.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Intrauterine growth restriction (IUGR) is associated with an increased risk of cardiovascular disease in adult life. Placental restriction (PR) in sheep results in chronic hypoxaemia and early onset IUGR with increased circulating plasma noradrenaline concentrations. These IUGR fetuses exhibit a greater decrease in mean arterial pressure (MAP) during \u03b1\u2010adrenergic blockade. We aimed to determine the role of post\u2010ganglionic sympathetic activation with respect to regulating MAP in IUGR fetal sheep. PR was induced by carunclectomy surgery prior to conception. Fetal vascular catheterization was performed at 110\u2013126\u00a0days gestational age (GA) (term, 150 days) in nine control and seven PR\u2010IUGR fetuses. The fetal blood pressure response to both a post\u2010ganglionic and an \u03b1\u2010adrenergic receptor blocker was assessed at 116\u2013120\u00a0days GA and\/or 129\u2013131\u00a0days GA. The effect of both post ganglionic and \u03b1\u2010adrenergic blockade on fetal blood pressure was then compared between control and IUGR fetuses at both GAs. There was no difference in the effect of post\u2010ganglionic blockade on MAP in control and IUGR fetal sheep at either 116\u2013120\u00a0days GA or 129\u2013131\u00a0days GA. \u03b1\u2010adrenergic receptor blockade decreased MAP to the same extent in both control and IUGR fetuses at 116\u2013120\u00a0days GA. At 129\u2013131\u00a0days GA, the drop in MAP in response to \u03b1\u2010adrenergic receptor blockade was greater in IUGR fetuses than controls. There was a significant inverse relationship between the drop in MAP in response to \u03b1\u2010adrenergic receptor blockade at both GAs with fetal <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp14494-math-0002.png\" xlink:title=\"urn:x-wiley:00223751:media:tjp14494:tjp14494-math-0002\"\/>. Thus, the increased dependence on \u03b1\u2010adrenergic activation for blood pressure regulation in the chronically hypoxaemic IUGR fetus is not a result of increased post\u2010ganglionic sympathetic activation.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jp280693","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T14:34:04Z","timestamp":1608647644000},"page":"1307-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The reliance on \u03b1\u2010adrenergic receptor stimuli for blood pressure regulation in the chronically hypoxaemic fetus is not dependent on post\u2010ganglionic activation"],"prefix":"10.1113","volume":"599","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-3920","authenticated-orcid":false,"given":"Jack R. 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