{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:20:03Z","timestamp":1775978403592,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The margin of human viability has extended to the extremes of gestational age (&lt;24 weeks) when the lungs are immature and ventilator\u2010induced lung injury is common.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Artificial placenta technology aims to extend gestation\n                            <jats:italic>ex utero<\/jats:italic>\n                            in order to allow the lungs additional time to develop prior to entering an air\u2010breathing environment.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            We compared the haemodynamics and cerebral oxygenation of piglets in the immediate period post\u2010oxygenator (OXY) transition against both paired\n                            <jats:italic>in utero<\/jats:italic>\n                            measures and uniquely against piglets transitioned onto mechanical ventilation (VENT).\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Post\u2010transition, OXY piglets became hypotensive with reduced carotid blood flow in comparison with both paired\n                            <jats:italic>in utero<\/jats:italic>\n                            measures and VENT piglets.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The addition of a pump to the oxygenator circuit may be required to ensure haemodynamic stability in the immediate post\u2010transition period.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Gestational age at birth is a major predictor of wellbeing; the lower the gestational age, the greater the risk of mortality and morbidity. At the margins of human viability (&lt;24 weeks gestation) immature lungs combined with the need for early ventilatory support means lung injury and respiratory morbidity is common. The abrupt haemodynamic changes consequent on birth may also contribute to preterm\u2010associated brain injury, including intraventricular haemorrhage. Artificial placenta technology aims to support oxygenation, haemodynamic stability and ongoing fetal development\n                      <jats:italic>ex utero<\/jats:italic>\n                      until mature enough to safely transition to a true\n                      <jats:italic>ex utero<\/jats:italic>\n                      environment. We aimed to characterize the impact of birth transition onto either an oxygenator circuit or positive pressure ventilation on haemodynamic and cerebral oxygenation of the neonatal piglet. At 112 days gestation (term\u00a0=\u00a0115 days), fetal pigs underwent instrumentation surgery and transitioned onto either an oxygenator (OXY,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05) or ventilatory support (VENT,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08). Blood pressure (BP), carotid blood flow and cerebral oxygenation in VENT piglets rose from\n                      <jats:italic>in utero<\/jats:italic>\n                      levels to be significantly higher than OXY piglets post\u2010transition. OXY piglet BP, carotid blood flow and carotid oxygen delivery (DO\n                      <jats:sub>2<\/jats:sub>\n                      ) decreased from\n                      <jats:italic>in utero<\/jats:italic>\n                      levels post\u2010transition; however, cerebral regional oxygen saturation (rSO\n                      <jats:sub>2<\/jats:sub>\n                      ) was maintained at fetal\u2010like levels. OXY piglets became hypoxaemic and retained CO\n                      <jats:sub>2<\/jats:sub>\n                      . Whether OXY piglets are able to maintain cerebral rSO\n                      <jats:sub>2<\/jats:sub>\n                      under these conditions for a prolonged period is yet to be determined. Improvements to OXY piglet oxygenation may lie in maintaining piglet BP at\n                      <jats:italic>in utero<\/jats:italic>\n                      levels and enhancing oxygenator circuit flow.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp280803","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T04:09:27Z","timestamp":1616299767000},"page":"2751-2761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Haemodynamics and cerebral oxygenation of neonatal piglets in the immediate\n                    <i>ex utero<\/i>\n                    period supported by mechanical ventilation or\n                    <i>ex utero<\/i>\n                    oxygenator"],"prefix":"10.1113","volume":"599","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-3920","authenticated-orcid":false,"given":"Jack R.T.","family":"Darby","sequence":"first","affiliation":[{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-6790","authenticated-orcid":false,"given":"Mary J.","family":"Berry","sequence":"additional","affiliation":[{"name":"Centre for Translational Physiology University of Otago  Wellington New Zealand"},{"name":"Department of Paediatrics and Child Health University of Otago  Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9687-4877","authenticated-orcid":false,"given":"Megan","family":"Quinn","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6326-4797","authenticated-orcid":false,"given":"Stacey L.","family":"Holman","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-8238","authenticated-orcid":false,"given":"Emma L.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-9317","authenticated-orcid":false,"given":"Sarah M.","family":"Jesse","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9716-8197","authenticated-orcid":false,"given":"Christoph","family":"Haller","sequence":"additional","affiliation":[{"name":"Univeristy of Toronto and The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7330-234X","authenticated-orcid":false,"given":"Mike","family":"Seed","sequence":"additional","affiliation":[{"name":"Univeristy of Toronto and The Hospital for Sick Children  Toronto Ontario 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