{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T19:00:16Z","timestamp":1774551616682,"version":"3.50.1"},"reference-count":158,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010fat diet (HFD) consumption is known to be associated with ovulatory disorders among women of reproductive age. Previous studies in animal models suggest that HFD\u2010induced microglia activation contributes to hypothalamic inflammation. This causes the dysfunction of the hypothalamic\u2013pituitary\u2013ovarian (HPO) axis, leading to subfertility. Sodium\u2013glucose cotransporter 2 (SGLT2) inhibitors are a novel class of lipid\u2010soluble antidiabetic drugs that target primarily the early proximal tubules in kidney. Recent evidence revealed an additional expression site of SGLT2 in the central nervous system (CNS), indicating a promising role of SGLT2 inhibitors in the CNS. In type 2 diabetes patients and rodent models, SGLT2 inhibitors exhibit neuroprotective properties through reduction of oxidative stress, alleviation of cerebral atherosclerosis and suppression of microglia\u2010induced neuroinflammation. Furthermore, clinical observations in patients with polycystic ovary syndrome (PCOS) demonstrated that SGLT2 inhibitors ameliorated patient anthropometric parameters, body composition and insulin resistance. Therefore, it is of importance to explore the central mechanism of SGLT2 inhibitors in the recovery of reproductive function in patients with PCOS and obesity. Here, we review the hypothalamic inflammatory mechanisms of HFD\u2010induced microglial activation, with a focus on the clinical utility and possible mechanism of SGLT2 inhibitors in promoting reproductive fitness.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15247-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp283259","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T15:44:45Z","timestamp":1662047085000},"page":"4549-4568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sodium\u2013glucose cotransporter 2 inhibitor ameliorates high fat diet\u2010induced hypothalamic\u2013pituitary\u2013ovarian axis disorders"],"prefix":"10.1113","volume":"600","author":[{"given":"Xiaolin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biomedical Science University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Infertility Chengdu Women's and Children's Central Hospital School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoni","family":"Xiao","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-534X","authenticated-orcid":false,"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biomedical Science University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227901"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.167"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(99)00113-3"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00722"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1190"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102278"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12171"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1595-4"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65928"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0093"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab392"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15267-z"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.08.008"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0027-16.2016"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.05.1758"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.06.010"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.11.1013"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.897628"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00698-0"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02183-2"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-16-0341"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4838-9"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12665"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf1230"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0262-0"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012339118"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-21-0449"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00058"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20200278"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.06.035"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118076"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab408"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2102-11.2011"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0191"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0404-6"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150237"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173040"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00833-x"},{"key":"e_1_2_2_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194637"},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa108"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2046"},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1331"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-016-0417-5"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.11.004"},{"key":"e_1_2_2_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9030057"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0242-x"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00607-4"},{"key":"e_1_2_2_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110615"},{"key":"e_1_2_2_51_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-20-0290"},{"key":"e_1_2_2_52_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.002758"},{"key":"e_1_2_2_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.246"},{"key":"e_1_2_2_54_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.59790"},{"key":"e_1_2_2_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2021.100968"},{"key":"e_1_2_2_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1769-z"},{"key":"e_1_2_2_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4320"},{"key":"e_1_2_2_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13968"},{"key":"e_1_2_2_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2532-9"},{"key":"e_1_2_2_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24771"},{"key":"e_1_2_2_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.09.028"},{"key":"e_1_2_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.010"},{"key":"e_1_2_2_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15983-6"},{"key":"e_1_2_2_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.12.016"},{"key":"e_1_2_2_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.08.013"},{"key":"e_1_2_2_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104870"},{"key":"e_1_2_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2019.03.012"},{"key":"e_1_2_2_68_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.120063"},{"key":"e_1_2_2_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01992"},{"key":"e_1_2_2_70_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.6.042"},{"key":"e_1_2_2_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.025"},{"key":"e_1_2_2_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2562"},{"key":"e_1_2_2_73_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1223"},{"key":"e_1_2_2_74_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011247"},{"key":"e_1_2_2_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-014-0148-1"},{"key":"e_1_2_2_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-021-01430-y"},{"key":"e_1_2_2_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00215"},{"key":"e_1_2_2_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0418-z"},{"key":"e_1_2_2_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30002-6"},{"key":"e_1_2_2_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0091-5"},{"key":"e_1_2_2_81_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1750"},{"key":"e_1_2_2_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01797-2"},{"key":"e_1_2_2_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02664"},{"key":"e_1_2_2_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0566-1"},{"key":"e_1_2_2_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-019-0387-y"},{"key":"e_1_2_2_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43134"},{"key":"e_1_2_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.014"},{"key":"e_1_2_2_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines7010005"},{"key":"e_1_2_2_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00424"},{"key":"e_1_2_2_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2760-08.2009"},{"key":"e_1_2_2_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170546"},{"key":"e_1_2_2_92_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1740"},{"key":"e_1_2_2_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163469"},{"key":"e_1_2_2_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2021.12.001"},{"key":"e_1_2_2_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030648"},{"key":"e_1_2_2_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.747620"},{"key":"e_1_2_2_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009156118"},{"key":"e_1_2_2_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081704"},{"key":"e_1_2_2_99_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1569-09.2009"},{"key":"e_1_2_2_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.028"},{"key":"e_1_2_2_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.011"},{"key":"e_1_2_2_102_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa146"},{"key":"e_1_2_2_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.050"},{"key":"e_1_2_2_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.06.035"},{"key":"e_1_2_2_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.12.007"},{"key":"e_1_2_2_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.70"},{"key":"e_1_2_2_107_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.3916"},{"key":"e_1_2_2_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13139"},{"key":"e_1_2_2_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2019.08.010"},{"key":"e_1_2_2_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1513853113"},{"key":"e_1_2_2_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-00997-7"},{"key":"e_1_2_2_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.026"},{"key":"e_1_2_2_113_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0584"},{"key":"e_1_2_2_114_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_2_2_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1024-1"},{"key":"e_1_2_2_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0701-9"},{"key":"e_1_2_2_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052576"},{"key":"e_1_2_2_118_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.116.142786"},{"key":"e_1_2_2_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.598707"},{"key":"e_1_2_2_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.08.005"},{"key":"e_1_2_2_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04468-5"},{"key":"e_1_2_2_122_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.161246"},{"key":"e_1_2_2_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.058665"},{"key":"e_1_2_2_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.05.013"},{"key":"e_1_2_2_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11441-0"},{"key":"e_1_2_2_126_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.137414"},{"key":"e_1_2_2_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0212-1"},{"key":"e_1_2_2_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107989"},{"key":"e_1_2_2_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14495"},{"key":"e_1_2_2_130_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018101064"},{"key":"e_1_2_2_131_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59660"},{"key":"e_1_2_2_132_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1406"},{"key":"e_1_2_2_133_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1156"},{"key":"e_1_2_2_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.017"},{"key":"e_1_2_2_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.04.019"},{"key":"e_1_2_2_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.11.018"},{"key":"e_1_2_2_137_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060580"},{"key":"e_1_2_2_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.02.014"},{"key":"e_1_2_2_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04376-5"},{"key":"e_1_2_2_140_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201810248"},{"key":"e_1_2_2_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.09.016"},{"key":"e_1_2_2_142_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5848-09.2010"},{"key":"e_1_2_2_143_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4363-08.2009"},{"key":"e_1_2_2_144_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511002868"},{"key":"e_1_2_2_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa029"},{"key":"e_1_2_2_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.595373"},{"key":"e_1_2_2_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0635-5"},{"key":"e_1_2_2_148_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812389"},{"key":"e_1_2_2_149_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00711"},{"key":"e_1_2_2_150_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.21172"},{"key":"e_1_2_2_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.08.008"},{"key":"e_1_2_2_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15143"},{"key":"e_1_2_2_153_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00317.2012"},{"key":"e_1_2_2_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-020-05553-5"},{"key":"e_1_2_2_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.043"},{"key":"e_1_2_2_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.10.003"},{"key":"e_1_2_2_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12651"},{"key":"e_1_2_2_158_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_2_2_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1538-9"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP283259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP283259","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP283259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:29:47Z","timestamp":1692581387000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP283259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":158,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1113\/JP283259"],"URL":"https:\/\/doi.org\/10.1113\/jp283259","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,20]]},"assertion":[{"value":"2022-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}