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Although MV is a life\u2010saving intervention for patients in respiratory failure, an unintended side\u2010effect of MV is the rapid development of diaphragmatic atrophy and contractile dysfunction. This MV\u2010induced diaphragmatic weakness is labelled as \u2018ventilator\u2010induced diaphragm dysfunction\u2019 (VIDD). VIDD is an important clinical problem because diaphragmatic weakness is a risk factor for the failure to wean patients from MV. Indeed, the inability to remove patients from ventilator support results in prolonged hospitalization and increased morbidity and mortality. The pathogenesis of VIDD has been extensively investigated, revealing that increased mitochondrial production of reactive oxygen species within diaphragm muscle fibres promotes a cascade of redox\u2010regulated signalling events leading to both accelerated proteolysis and depressed protein synthesis. Together, these events promote the rapid development of diaphragmatic atrophy and contractile dysfunction. This review highlights the MV\u2010induced changes in the structure\/function of diaphragm muscle and discusses the cell\u2010signalling mechanisms responsible for the pathogenesis of VIDD. This report concludes with a discussion of potential therapeutic opportunities to prevent VIDD and suggestions for future research in this exciting field.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16287-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp283860","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T15:28:06Z","timestamp":1725118086000},"page":"4729-4752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Ventilator\u2010induced diaphragm dysfunction: phenomenology and mechanism(s) of 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