{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:04:37Z","timestamp":1782421477746,"version":"3.54.5"},"reference-count":83,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>The carotid body (CB) is a prototypical acute oxygen (O<jats:sub>2<\/jats:sub>)\u2010sensing organ that mediates reflex hyperventilation and increased cardiac output in response to hypoxaemia. CB overactivation, secondary to the repeated stimulation produced by the recurrent episodes of intermittent hypoxia, is believed to contribute to the pathogenesis of sympathetic hyperactivity present in sleep apnoea patients. Although CB functional plasticity induced by chronic intermittent hypoxia (CIH) has been demonstrated, the underlying mechanisms are not fully elucidated. Here, we show that CIH induces a small increase in CB volume and rearrangement of cell types in the CB, characterized by a mobilization of immature quiescent neuroblasts, which enter a process of differentiation into mature, O<jats:sub>2<\/jats:sub>\u2010sensing and neuron\u2010like, chemoreceptor glomus cells. Prospective isolation of individual cell classes has allowed us to show that maturation of CB neuroblasts is paralleled by an upregulation in the expression of specific glomus cell genes involved in acute O<jats:sub>2<\/jats:sub>\u2010sensing. CIH enhances mitochondrial responsiveness to hypoxia in maturing neuroblasts as well as in glomus cells. These data provide novel perspectives on the pathogenesis of CB\u2010mediated sympathetic overflow that may lead to the development of new pharmacological strategies of potential applicability in sleep apnoea patients.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15426-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Obstructive sleep apnoea is a frequent condition in the human population that predisposes to severe cardiovascular and metabolic alterations.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Activation of the carotid body, the main arterial oxygen\u2010sensing chemoreceptor, by repeated episodes of hypoxaemia induces exacerbation of the carotid body\u2010mediated chemoreflex and contributes to sympathetic overflow characteristic of sleep apnoea patients.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In rats, chronic intermittent hypoxaemia induces fast neurogenesis in the carotid body with rapid activation of neuroblasts, which enter a process of proliferation and maturation into O<jats:sub>2<\/jats:sub>\u2010sensing chemoreceptor glomus cells.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Maturing carotid body neuroblasts and glomus cells exposed to chronic intermittent hypoxia upregulate genes involved in acute O<jats:sub>2<\/jats:sub> sensing and enhance mitochondrial responsiveness to hypoxia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These findings provide novel perspectives on the pathogenesis of carotid body\u2010mediated sympathetic hyperactivation. Pharmacological modulation of carotid body fast neurogenesis could help to ameliorate the deleterious effects of chronic intermittent hypoxaemia in sleep apnoea patients.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp283897","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T09:46:35Z","timestamp":1673948795000},"page":"1017-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia"],"prefix":"10.1113","volume":"601","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6428-0027","authenticated-orcid":false,"given":"Candela","family":"Caballero\u2010Eraso","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS) Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Seville 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