{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:31:16Z","timestamp":1791549076505,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"\n Abstract<\/jats:title>\n \n This study aimed to clarify whether aerobic exercise training\u2010induced alterations in the gut microbiota affect physiological adaptation with endurance exercise capacity. In study 1, ICR mice were randomly divided into three groups: vehicle intake + sedentary (V+S), vehicle intake + exercise training (V+Ex) and antibiotic intake + exercise training (AB+Ex). In the exercise training groups, treadmill running was performed for 8\u00a0weeks. During the exercise training intervention, the antibiotic\u2010intake group freely drank water containing antibiotics. In study 2, ICR mice were randomly divided into three groups: Sham, transplantation of caecum microbiota from sedentary mice (Sed\u2010CMT) and exercise training mice (Ex\u2010CMT). In study 1, the treadmill running time to exhaustion, an index of maximal aerobic capacity, after aerobic exercise training in the V+Ex group was significantly longer than that in the V+S and AB+Ex groups. Gastrocnemius muscle citrate synthase (CS) activity and PGC\u20101\u03b1 protein levels in the V+Ex group were significantly higher than in the V+S and AB+Ex groups. The bacterial\n Erysipelotrichaceae<\/jats:italic>\n and\n Alcaligenaceae<\/jats:italic>\n families were positively correlated with treadmill running time to exhaustion. In study 2, the treadmill running time to exhaustion after transplantation was significantly higher in the Ex\u2010CMT group than in the Sham and Sed\u2010CMT groups. Furthermore, CS activity and PGC\u20101\u03b1 protein levels in the gastrocnemius muscle were significantly higher in the Ex\u2010CMT group than in the Sham and Sed\u2010CMT groups. Thus, gut microbiota altered by aerobic exercise training may be involved in the augmentation of endurance capacity and muscle mitochondrial energy metabolism.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n \n Aerobic exercise training changes gut microbiota composition, and the\n Erysipelotrichaceae<\/jats:italic>\n and\n Alcaligenaceae<\/jats:italic>\n families were among the altered gut bacteria.\n <\/jats:p>\n <\/jats:list-item>\n \n The gut microbiota was associated with endurance performance and metabolic regulator levels in skeletal muscle after aerobic exercise training.<\/jats:p>\n <\/jats:list-item>\n \n Continuous antibiotic treatment attenuated the increase in endurance performance, citrate synthase activity and PGC\u20101\u03b1 levels in skeletal muscle induced by aerobic exercise training.<\/jats:p>\n <\/jats:list-item>\n \n Gut microbiota transplantation from exercise\u2010trained mice improved endurance performance and metabolic regulator levels in recipient skeletal muscle, despite the absence of aerobic exercise training.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1113\/jp283995","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T01:25:15Z","timestamp":1681435515000},"page":"2329-2344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Aerobic exercise training\u2010induced alteration of gut microbiota composition affects endurance capacity"],"prefix":"10.1113","volume":"601","author":[{"given":"Masataka","family":"Uchida","sequence":"first","affiliation":[{"name":"Ritsumeikan\u2010Global Innovation Research Organization Ritsumeikan University Kusatsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumpei","family":"Fujie","sequence":"additional","affiliation":[{"name":"Faculty of Sport and Health Science Ritsumeikan University Kusatsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Health and Sports Science Kawasaki University of Medical Welfare Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-6030","authenticated-orcid":false,"given":"Motoyuki","family":"Iemitsu","sequence":"additional","affiliation":[{"name":"Faculty of Sport and Health Science Ritsumeikan University Kusatsu Shiga 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