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This information initiates vago\u2010vagal reflexes essential for gut functions, including gut motility and secretions. These afferents also play a role in energy homeostasis, signalling the arrival, amount and nutrient composition of a meal to the central nervous system where it is processed ultimately leading to termination of a meal. Vagal afferent responses to food related stimuli demonstrate a high degree of plasticity, responding to short term changes in nutritional demand, such as the fluctuations that occur across a 24\u2010hr or in response to a fast, as well as long term changes in energy demand, such as occurs during pregnancy. This plasticity is disrupted in disease states, such as obesity or chronic stress where there is hypo\u2010 and hypersensitivity of these afferents, respectively. Improved understanding of the plasticity of these afferents will enable identification of new treatment options for diseases associated with vagal afferent function.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15740-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp284075","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T10:20:10Z","timestamp":1695378010000},"page":"4763-4776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasticity of gastrointestinal vagal afferents in terms of feeding\u2010related physiology and pathophysiology"],"prefix":"10.1113","volume":"602","author":[{"given":"Amanda J.","family":"Page","sequence":"first","affiliation":[{"name":"Vagal Afferent Research Group, School of Biomedicine University of Adelaide  Adelaide South Australia Australia"},{"name":"Nutrition, Diabetes &amp; Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute SAHMRI  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804938115"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp016905"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01710-0"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.039"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.031"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0195-7"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2017.29.52-57"},{"issue":"3","key":"e_1_2_2_9_1","first-page":"G334","article-title":"Antral control of canine gastric emptying of solids","volume":"245","author":"Becker J. 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