{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:58:28Z","timestamp":1785463108230,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25670121"],"award-info":[{"award-number":["25670121"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H05536"],"award-info":[{"award-number":["17H05536"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>\n \n Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of cation channels, is broadly expressed in sensory neural pathways, including the trigeminal neurons innervating the nasal cavity and vagal neurons innervating the trachea and the lung. TRPA1 acts as a detector of various irritant chemicals as well as hypoxia and hyperoxia. For the past 15\u00a0years, we have characterised its role in respiratory and behavioural modulation\n in vivo<\/jats:italic>\n using\n Trpa1<\/jats:italic>\n knockout (KO) mice and wild\u2010type (WT) littermates.\n Trpa1<\/jats:italic>\n KO mice failed to detect, wake up from sleeping, and escape from formalin vapour and a mild hypoxic (15% O\n 2<\/jats:sub>\n ) environment. Respiratory augmentation induced by mild hypoxia was absent in either\n Trpa1<\/jats:italic>\n KO mice or WT mice treated with a TRPA1 antagonist. Irritant gas introduced into the nasal cavity inhibited respiratory responses in WT mice but not in the KO mice. The effect of TRPA1 on the olfactory system seemed minimal because olfactory bulbectomized WT mice reacted similarly to the intact mice. Immunohistological analyses using a cellar activation marker, the phosphorylated form of extracellular signal\u2010regulated kinase, confirmed activation of trigeminal neurons in WT mice but not in\n Trpa1<\/jats:italic>\n KO mice in response to irritant chemicals and mild hypoxia. These data collectively show that TRPA1 is necessary for multiple chemical\u2010induced protective responses in respiration and behaviour. We propose that TRPA1 channels in the airway may play a sentinel role for environmental threats and prevent incoming damage.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>","DOI":"10.1113\/jp284076","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T23:10:30Z","timestamp":1683328230000},"page":"4755-4762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["TRPA1 channel in the airway underlies protection against airborne threats by modulating respiration and behaviour"],"prefix":"10.1113","volume":"602","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-3610","authenticated-orcid":false,"given":"Tomoyuki","family":"Kuwaki","sequence":"first","affiliation":[{"name":"Department of Physiology, Graduate School of Medical and Dental Sciences Kagoshima University Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-3921","authenticated-orcid":false,"given":"Nobuaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"The Hakubi Center for Advanced Research & Department of Synthetic Chemistry and Biological Chemistry Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,14]]},"reference":[{"key":"e_1_2_2_2_1","unstructured":"Akahoshi R. Katayama Y. Yamaguchi R. Yonemitsu T. Pauli J. L. Kashiwadani H. &Kuwaki T.(2016).TRPA1 is indispensable to escaping from predator. In SfN Annual Meeting Abstract 724.06. 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