{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:51:25Z","timestamp":1791993085881,"version":"4.4.0"},"reference-count":80,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>The response of spinal motoneurons to synaptic input greatly depends on the activation of persistent inward currents (PICs), which in turn are enhanced by the neuromodulators serotonin and noradrenaline. Local vibration (LV) induces excitatory Ia input onto motoneurons and may alter neuromodulatory inputs. Therefore, we investigated whether LV influences the contribution of PICs to motoneuron firing. This was assessed in voluntary contractions with concurrent, ongoing LV, as well as after a bout of prolonged LV. High\u2010density surface electromyograms (HD\u2010EMG) of the tibialis anterior were recorded with a 64\u2010electrode matrix. Twenty males performed isometric, triangular, dorsiflexion contractions to 20% and 50% of maximal torque at baseline, during LV of the tibialis anterior muscle, and after 30\u2010min of LV. HD\u2010EMG signals were decomposed, and motor units tracked across time points to estimate PICs through a paired motor unit analysis, which quantifies motor unit recruitment\u2013derecruitment hysteresis (\u0394<jats:italic>F<\/jats:italic>). During ongoing LV, \u0394<jats:italic>F<\/jats:italic> was lower for both 20% and 50% ramps. Although significant changes in \u0394<jats:italic>F<\/jats:italic> were not observed after prolonged LV, a differential effect across the motoneuron pool was observed. This study demonstrates that PICs can be non\u2010pharmacologically modulated by LV. Given that LV leads to reflexive motor unit activation, it is postulated that lower PIC contribution to motoneuron firing during ongoing LV results from decreased neuromodulatory inputs associated with lower descending corticospinal drive. A differential effect in motoneurons of different recruitment thresholds after prolonged LV is provocative, challenging the interpretation of previous observations and motivating future investigations.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15485-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Neuromodulatory inputs from the brainstem influence motoneuron intrinsic excitability through activation of persistent inward currents (PICs). PICs make motoneurons more responsive to excitatory input.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We demonstrate that vibration applied on the muscle modulates the contribution of PICs to motoneuron firing, as observed through analysis of the firing of single motor units.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The effects of PICs on motoneuron firing were lower when vibration was concurrently applied during voluntary ramp contractions, likely due to lower levels of neuromodulation. Additionally, prolonged exposure to vibration led to differential effects of lower\u2010 <jats:italic>vs<\/jats:italic>. higher\u2010threshold motor units on PICs, with lower\u2010threshold motor units tending to present an increased and higher\u2010threshold motor units a decreased contribution of PICs to motoneuron firing.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results demonstrate that muscle vibration has the potential to influence the effects of neuromodulation on motoneuron firing. The potential of using vibration as a non\u2010pharmacological neuromodulatory intervention should be further investigated.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp284210","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T12:21:27Z","timestamp":1677846087000},"page":"1467-1482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Can local vibration alter the contribution of persistent inward currents to human motoneuron firing?"],"prefix":"10.1113","volume":"601","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-6614","authenticated-orcid":false,"given":"T.","family":"Lapole","sequence":"first","affiliation":[{"name":"Universit\u00e9 Jean Monnet Saint\u2010Etienne, Lyon 1, Universit\u00e9 Savoie Mont\u2010Blanc Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-3253","authenticated-orcid":false,"given":"R. 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O.","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering Chalmers University of Technology  Gothenburg Sweden"},{"name":"School of Medical and Health Sciences Edith Cowan University  Perth Australia"},{"name":"Neuroscience Research Australia  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1368-0848","authenticated-orcid":false,"given":"S.","family":"Baudry","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biology, Research Unit in Applied Neurophysiology (LABNeuro), Faculty of Motor Sciences Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Souron","sequence":"additional","affiliation":[{"name":"Movement\u2013Interactions\u2013Performance, MIP, Nantes Universit\u00e9  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-8044","authenticated-orcid":false,"given":"C. 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