{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:37:36Z","timestamp":1783420656798,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01\u2010DC017119"],"award-info":[{"award-number":["R01\u2010DC017119"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020172","name":"Royal National Institute for Deaf People","doi-asserted-by":"publisher","award":["D007423"],"award-info":[{"award-number":["D007423"]}],"id":[{"id":"10.13039\/501100020172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>Hearing impairment without threshold elevations can occur when there is damage to high\u2010threshold auditory nerve fibre synapses with cochlear inner hair cells. Instead, cochlear synaptopathy produces suprathreshold deficits, especially in older patients, which affect conversational speech. Given that listening in noise at suprathreshold levels presents significant challenges to the ageing population, we examined the effects of synaptopathy on tone\u2010in\u2010noise coding on the central recipients of auditory nerve fibres, i.e. the cochlear nucleus neurons. To induce synaptopathy, guinea pigs received a unilateral sound overexposure to the left ears. A separate group received sham exposures. At 4\u00a0weeks post\u2010exposure, thresholds had recovered but reduced auditory brainstem response wave\u00a01 amplitudes and auditory nerve synapse loss remained on the left side. Single\u2010unit responses were recorded from several cell types in the ventral cochlear nucleus to pure\u2010tone and noise stimuli. Receptive fields and rate\u2013level functions in the presence of continuous broadband noise were examined. The synaptopathy\u2010inducing noise exposure did not affect mean unit tone\u2010in\u2010noise thresholds, nor the tone\u2010in\u2010noise thresholds in each animal, demonstrating equivalent tone\u2010in\u2010noise detection thresholds to sham animals. However, synaptopathy reduced single\u2010unit responses to suprathreshold tones in the presence of background noise, particularly in the cochlear nucleus small cells. These data demonstrate that suprathreshold tone\u2010in\u2010noise deficits following cochlear synaptopathy are evident in the first neural station of the auditory brain, the cochlear nucleus neurons, and provide a potential target for assessment and treatment of listening\u2010in\u2010noise deficits in humans.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15617-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Recording from multiple central auditory neurons can determine tone\u2010in\u2010noise deficits in animals with quantified cochlear synapse damage.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Using this technique, we found that tone\u2010in\u2010noise thresholds are not altered by cochlear synaptopathy, whereas coding of suprathreshold tones\u2010in\u2010noise is disrupted.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Suprathreshold deficits occur in small cells and primary\u2010like neurons of the cochlear nucleus.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data provide important insights into the mechanisms underlying difficulties associated with hearing in noisy environments.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp284452","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T10:11:13Z","timestamp":1684750273000},"page":"2991-3006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cochlear synaptopathy impairs suprathreshold tone\u2010in\u2010noise coding in the cochlear nucleus"],"prefix":"10.1113","volume":"601","author":[{"given":"A.","family":"Hockley","sequence":"first","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology University of Michigan  Ann Arbor MI USA"},{"name":"Instituto de Neurociencias de Castilla y Le\u00f3n Universidad de Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. R.","family":"Cassinotti","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Selesko","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Corfas","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5300-5492","authenticated-orcid":false,"given":"S. E.","family":"Shore","sequence":"additional","affiliation":[{"name":"Kresge Hearing Research Institute, Department of Otolaryngology University of Michigan  Ann Arbor MI USA"},{"name":"Department of Molecular and Integrative Physiology University of Michigan  Ann Arbor MI USA"},{"name":"Department of Biomedical Engineering University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309130911"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1984.51.6.1326"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108021"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00164.2013"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12386-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.4.2083"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/909260"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.03.008"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.2949518"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2104-20.2020"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.684706"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14572"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP282262"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3103-17.2018"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903130205"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.12.009"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-011-0283-2"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-24-10891.2002"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.09.046"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2021.747472"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072221"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3240-17.2018"},{"issue":"2","key":"e_1_2_5_24_1","first-page":"2S11","article-title":"Effects of aging on auditory processing of speech","volume":"42","author":"Pichora\u2010Fuller M. K.","year":"2003","journal-title":"International Journal of Audiology"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10010035"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.03.067"},{"issue":"1","key":"e_1_2_5_27_1","first-page":"1","article-title":"Tone\u2010in\u2010noise detection deficits in elderly patients with clinically normal hearing","volume":"40","author":"Ralli M.","year":"2019","journal-title":"American Journal of Otolaryngology \u2010 Head and Neck Medicine and Surgery"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.01.015"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00006-3"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.10.052"},{"issue":"70","key":"e_1_2_5_31_1","first-page":"1","article-title":"Subcollicular projections to the auditory thalamus and collateral projections to the inferior colliculus","volume":"8","author":"Schofield B. R.","year":"2014","journal-title":"Frontiers in Neuroanatomy"},{"issue":"10","key":"e_1_2_5_32_1","first-page":"1","article-title":"Projections from the dorsal and ventral cochlear nuclei to the medial geniculate body","volume":"8","author":"Schofield B. R.","year":"2014","journal-title":"Frontiers in Neuroanatomy"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2018.27.5.397"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081566"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.3.1667"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.04.014"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6538-10.2011"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03564"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281014"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.1.141"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.07.053"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1988.60.1.1"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.393530"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.02.038"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP284452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T16:35:14Z","timestamp":1692290114000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP284452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":43,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1113\/JP284452"],"URL":"https:\/\/doi.org\/10.1113\/jp284452","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,30]]},"assertion":[{"value":"2023-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}