{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:00:18Z","timestamp":1784793618382,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension are the main precapillary forms of pulmonary hypertension (PH) summarized as pulmonary vascular diseases (PVD). PVDs are characterized by exertional dyspnoea and oxygen desaturation, and reduced quality of life and survival. Medical therapies improve life expectancy and physical performance of PVD patients, of whom many wish to participate in professional work and recreational activities including traveling to high altitude. The exposure to the hypobaric hypoxic environment of mountain regions incurs the risk of high altitude adverse events (AE<jats:sub>HA<\/jats:sub>) due to severe hypoxaemia exacerbating symptoms and further increase in pulmonary artery pressure, which may lead to right heart decompensation. Recent prospective and randomized trials show that altitude\u2010induced hypoxaemia, pulmonary haemodynamic changes and impairment of exercise performance in PVD patients are in the range found in healthy people. The vast majority of optimally treated stable PVD patients who do not require long\u2010term oxygen therapy at low altitude can tolerate short\u2010term exposure to moderate altitudes up to 2500\u00a0m. PVD patients that reveal persistent severe resting hypoxaemia (\u00a0&lt;80% for &gt;30\u00a0min) at 2500\u00a0m respond well to supplemental oxygen therapy. Although there are no accurate predictors for AE<jats:sub>HA<\/jats:sub>, PVD patients with unfavourable risk profiles at low altitude, such as higher WHO functional class, lower exercise capacity with more pronounced exercise\u2010induced desaturation and more severely impaired haemodynamics, are at increased risk of AE<jats:sub>HA<\/jats:sub>. Therefore, doctors with experience in PVD and high\u2010altitude medicine should counsel PVD patients before any high\u2010altitude sojourn. This review aims to summarize recent literature and clinical recommendations about PVD patients travelling to high altitude.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16101-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp284585","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:35:32Z","timestamp":1716478532000},"page":"5505-5513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Symposium review: high altitude travel with pulmonary vascular 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