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For years, clinicians have been trying to find the underlying diagnosis and using existing disease models to describe the patients\u2019 illness. This presents a confusing picture of CC. Most patients with CC present with hypersensitivity of the cough reflex, which is characterised by laryngeal paraesthesia and an increased response to the tussive stimuli or an innocuous stimulus that would not trigger coughing in healthy people. Recently, it has been proposed that CC is a unique disease characterised by vagal hypersensitivity that projects to the central nervous system altering responsiveness. The evidence supports the hypothesis that CC is primarily a neurological disorder, consisting of different phenotypes.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15705-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp284641","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:18:47Z","timestamp":1693297127000},"page":"6039-6046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Unravelling vagal hypersensitivity in chronic cough: A distinct disease"],"prefix":"10.1113","volume":"602","author":[{"given":"Mengru","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine Tongji University  Shanghai China"},{"name":"Centre for Clinical Science Respiratory Medicine Hull York Medical School University of Hull, Castle Hill Hospital  Cottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-4036","authenticated-orcid":false,"given":"Alyn H.","family":"Morice","sequence":"additional","affiliation":[{"name":"Centre for Clinical Science Respiratory Medicine Hull York Medical School University of Hull, Castle Hill Hospital  Cottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"e_1_2_2_2_1","unstructured":"European Medicines Agency(2016. 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