{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:40:43Z","timestamp":1787236843526,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL00785\u201048"],"award-info":[{"award-number":["T32HL00785\u201048"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K23HLi32048"],"award-info":[{"award-number":["1K23HLi32048"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002535"],"award-info":[{"award-number":["UL1TR002535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Acute hypoxia increases pulmonary arterial (PA) pressures, though its effect on right ventricular (RV) function is controversial. The objective of this study was to characterize exertional RV performance during acute hypoxia. Ten healthy participants (34\u00a0\u00b1\u00a010 years, 7\u00a0males) completed three visits: visits 1 and 2 included non\u2010invasive normoxic (fraction of inspired oxygen ()\u00a0=\u00a00.21) and isobaric hypoxic (\u00a0=\u00a00.12) cardiopulmonary exercise testing (CPET) to determine normoxic\/hypoxic maximal oxygen uptake (). Visit 3 involved invasive haemodynamic assessments where participants were randomized 1:1 to either Swan\u2013Ganz or conductance catheterization to quantify RV performance via pressure\u2013volume analysis. Arterial oxygen saturation was determined by blood gas analysis from radial arterial catheterization. During visit 3, participants completed invasive submaximal CPET testing at 50% normoxic  and again at 50% hypoxic  (\u00a0=\u00a00.12). Median (interquartile range) values for non\u2010invasive  values during normoxic and hypoxic testing were 2.98 (2.43, 3.66) l\/min and 1.84 (1.62, 2.25) l\/min, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). Mean PA pressure increased significantly when transitioning from rest to submaximal exercise during normoxic and hypoxic conditions (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0014). Metrics of RV contractility including preload recruitable stroke work, d\n                      <jats:italic>P<\/jats:italic>\n                      \/d\n                      <jats:italic>t<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      , and end\u2010systolic pressure increased significantly during the transition from rest to exercise under normoxic and hypoxic conditions. Ventricular\u2013arterial coupling was maintained during normoxic exercise at 50% . During submaximal exercise at 50% of hypoxic , ventricular\u2013arterial coupling declined but remained within normal limits. In conclusion, resting and exertional RV functions are preserved in response to acute exposure to hypoxia at an \u00a0=\u00a00.12 and the associated increase in PA pressures.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15956-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The healthy right ventricle augments contractility, lusitropy and energetics during periods of increased metabolic demand (e.g. exercise) in acute hypoxic conditions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>During submaximal exercise, ventricular\u2013arterial coupling decreases but remains within normal limits, ensuring that cardiac output and systemic perfusion are maintained.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These data describe right ventricular physiological responses during submaximal exercise under conditions of acute hypoxia, such as occurs during exposure to high altitude and\/or acute hypoxic respiratory failure.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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Critical Care Medicine University of Colorado  Aurora CO USA"},{"name":"Division of Pulmonary, Critical Care and Sleep Medicine National Jewish Health  Denver CO USA"},{"name":"Rocky Mountain Regional Veterans Affairs Medical Center  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Sisson","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Center University of Colorado Anschutz Medical Campus  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"O'Gean","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Center University of Colorado Anschutz Medical Campus  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-7966","authenticated-orcid":false,"given":"Justin S.","family":"Lawley","sequence":"additional","affiliation":[{"name":"Department of Sport Science University of Innsbruck  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