{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:36:32Z","timestamp":1780626992700,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001516","name":"National Heart Foundation of New Zealand","doi-asserted-by":"publisher","award":["19\/56"],"award-info":[{"award-number":["19\/56"]}],"id":[{"id":"10.13039\/501100001516","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>Sympathetic transduction is the study of how impulses of sympathetic nerve activity (SNA) affect end\u2010organ function. Recently, the transduction of resting bursts of muscle SNA (MSNA) has been investigated and shown to have a role in the maintenance of blood pressure through changes in vascular tone in humans. In the present study, we investigate whether directly recorded resting cardiac SNA (CSNA) regulates heart rate (HR), coronary blood flow (CoBF), coronary vascular conductance (CVC), cardiac output (CO) and mean arterial pressure. Instrumentation was undertaken to record CSNA and relevant vascular variables in conscious sheep. Recordings were performed at baseline, as well as after the infusion of a \u03b2\u2010adrenoceptor blocker (propranolol) to determine the role of \u03b2\u2010adrenergic signalling in sympathetic transduction in the heart. The results show that after every burst of CSNA, there was a significant effect of time on HR (<jats:italic>n<\/jats:italic>\u00a0=\u00a010, \u2206: +2.1\u00a0\u00b1\u00a01.4 beats\u00a0min<jats:sup>\u20131<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and CO (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, \u2206: +100\u00a0\u00b1\u00a0150\u00a0mL\u00a0min<jats:sup>\u20131<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) was elevated, followed by an increase in CoBF (<jats:italic>n<\/jats:italic>\u00a0=\u00a09, \u2206: +0.76\u00a0mL\u00a0min<jats:sup>\u20131<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and CVC (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, \u2206: +0.0038\u00a0mL\u00a0min<jats:sup>\u20131<\/jats:sup>\u00a0mmHg<jats:sup>\u20131<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0028). The changes in HR were graded depending on the size and pattern of CSNA bursts. The HR response was significantly attenuated after the infusion of propranolol. Our study is the first to explore resting sympathetic transduction in the heart, suggesting that CSNA can dynamically change HR mediated by an action on \u03b2\u2010adrenoceptors.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15926-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Sympathetic transduction is the study of how impulses of sympathetic nerve activity (SNA) affect end\u2010organ function.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Previous studies have examined sympathetic transduction primarily in the skeletal muscle and shown that bursts of muscle SNA alter blood flow to skeletal muscle and mean arterial pressure, although this has not been examined in the heart.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We investigated sympathetic transduction in the heart and show that, in the conscious condition, the size of bursts of SNA to the heart can result in incremental increases in heart rate and coronary blood flow mediated by \u03b2\u2010adrenoceptors.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The pattern of bursts of SNA to the heart also resulted in incremental increases in heart rate mediated by \u03b2\u2010adrenoceptors.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This is the first study to explore the transduction of bursts of SNA to the heart.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp285079","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T13:04:17Z","timestamp":1707397457000},"page":"619-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sympathetic transduction of cardiac sympathetic nerve activity in healthy, conscious sheep"],"prefix":"10.1113","volume":"602","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0047-7633","authenticated-orcid":false,"given":"Dilsha","family":"Gimhani","sequence":"first","affiliation":[{"name":"Department of Physiology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Shanks","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1863-7452","authenticated-orcid":false,"given":"Mridula","family":"Pachen","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-3413","authenticated-orcid":false,"given":"Joshua W\u2010H","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-1692","authenticated-orcid":false,"given":"Rohit","family":"Ramchandra","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.225334"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"R513","article-title":"Differential control of sympathetic nerve discharge by the brain stem","volume":"247","author":"Barman S. 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