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Recent evidence suggests the existence of an intimate cross\u2010talk between the heart and the brain, resulting from a complex network of neurohumoral circuits. From a pathophysiological perspective, the higher prevalence of AD in women may be explained, at least in part, by sex\u2010related differences in the incidence\/prevalence of CVD. Notably, the autonomic nervous system, the main heart\u2013brain axis physiological orchestrator, has been suggested to play a role in the incidence of adverse cardiovascular events in middle\u2010aged women because of decreases in oestrogen\u2010related signalling during transition into menopause. Despite its overt relevance for public health, this hypothesis has not been thoroughly tested. Accordingly, in this review, we aim to provide up to date evidence supporting how changes in circulating oestrogen levels during transition to menopause may trigger autonomic dysfunction, thus promoting cardiovascular and cognitive decline in women. A main focus on the effects of oestrogen\u2010mediated signalling at CNS structures related to autonomic regulation is provided, particularly on the role of oestrogens in sympathoexcitation. Improving the understanding of the contribution of the autonomic nervous system on the development, maintenance and\/or progression of both cardiovascular and cognitive dysfunction during the transition to menopause should help improve the clinical management of elderly women, with the outcome being an improved life quality during the natural ageing process.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15863-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp285126","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T12:45:15Z","timestamp":1702039515000},"page":"263-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Autonomic nervous system dysfunction throughout menopausal transition: A potential mechanism underpinning cardiovascular and cognitive alterations during female ageing"],"prefix":"10.1113","volume":"602","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2503-3402","authenticated-orcid":false,"given":"Karla G.","family":"Schwarz","sequence":"first","affiliation":[{"name":"Laboratory of Cardiorespiratory Control Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7630-2651","authenticated-orcid":false,"given":"Sinay C.","family":"Vicencio","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiorespiratory Control Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3118-9726","authenticated-orcid":false,"given":"Nibaldo C.","family":"Inestrosa","sequence":"additional","affiliation":[{"name":"Centro de Excelencia en Biomedicina de Magallanes (CEBIMA) Universidad de Magallanes  Punta Arenas Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-5881","authenticated-orcid":false,"given":"Paulina","family":"Villaseca","sequence":"additional","affiliation":[{"name":"Centro de Excelencia en Biomedicina de Magallanes (CEBIMA) Universidad de Magallanes  Punta Arenas Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2562-806X","authenticated-orcid":false,"given":"Rodrigo","family":"Del Rio","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiorespiratory Control Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Centro de Excelencia en Biomedicina de Magallanes (CEBIMA) Universidad de Magallanes  Punta Arenas Chile"},{"name":"Department of Cell Biology and Physiology, School of Medicine University of Kansas Medical Center  Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.177535"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-09-03608.2002"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases8030035"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20180589"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02393"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac076"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-021-00880-3"},{"issue":"3","key":"e_1_2_2_9_1","article-title":"Hormone therapy for preventing cardiovascular disease in post\u2010menopausal women","volume":"2015","author":"Boardman H. 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