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The existing functional neuroimaging literature has identified important neural and behavioural differences between normotensive and hypertensive individuals. However, previously\u2010used methods (i.e. magnetic resonance imaging, functional near\u2010infrared spectroscopy) rely on neurovascular coupling, which is a useful but indirect measure of neuronal activity. Furthermore, most studies fail to distinguish between controlled and uncontrolled hypertensive individuals, who exhibit significant behavioural and clinical differences. To partially remedy this gap in the literature, we used magnetoencephalography (MEG) to directly examine neuronal activity that is invariant to neurovascular coupling changes induced by hypertension. Our study included 52 participants (19\u00a0healthy controls, 15 controlled hypertensives, 18 uncontrolled hypertensives) who completed a modified flanker attention task during MEG. We identified significant oscillatory neural responses in two frequencies (alpha: 8\u201314\u00a0Hz, gamma: 48\u201360\u00a0Hz) for imaging and used grand\u2010averaged images to determine seeds for whole\u2010brain connectivity analysis. We then conducted Fisher\u2010<jats:italic>z<\/jats:italic> tests for each pair of groups, using the relationship between the neural connectivity and behavioural attention effects. This highlighted a distributed network of regions associated with cognitive control and selective attention, including frontal\u2010occipital and interhemispheric occipital connections. Importantly, the inferior frontal cortex exhibited a unique neurobehavioural relationship that distinguished the uncontrolled hypertensive group from the controlled hypertensive and normotensive groups. This is the first investigation of hypertension using MEG and identifies critical whole\u2010brain connectivity differences based on hypertension profiles.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16002-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Structural and functional changes in brain circuitry scale with hypertension severity and increase the risk of cognitive impairment and Alzheimer's disease.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We harness the excellent spatiotemporal precision of magnetoencephalography (MEG) to directly quantify dynamic functional connectivity in healthy control, controlled hypertensive and uncontrolled hypertensive groups during a flanker task.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In the first MEG study of hypertension, we show that there are neurobehavioural relationships that distinguish the uncontrolled hypertensive group from healthy and controlled hypertensive group in the prefrontal cortex.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results provide novel insights into the differential impact of hypertension on brain dynamics underlying selective attention.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp285568","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T08:04:32Z","timestamp":1711094672000},"page":"1775-1790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multispectral brain connectivity during visual attention distinguishes controlled from uncontrolled hypertension"],"prefix":"10.1113","volume":"602","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-9902","authenticated-orcid":false,"given":"Jake J.","family":"Son","sequence":"first","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Boys Town NE USA"},{"name":"College of Medicine University of Nebraska Medical Center  Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasra","family":"Arif","sequence":"additional","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Boys Town NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davina","family":"Oludipe","sequence":"additional","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Boys Town NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Weyrich","sequence":"additional","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Boys Town NE USA"},{"name":"Department of Pharmacology &amp; 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