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In this context, the neonatal immune system in the children of women with pregestational obesity is characterised by an altered inflammatory profile. The mechanisms that potentially affect the development and function of immune cells during fetal development, at birth and during the postnatal life in the children of women with obesity are unknown. Some insights into these mechanisms have been studied in animal models of maternal obesity; however, human studies are limited and are greatly required. This review aims to examine the impact of maternal obesity on fetal myeloid immune cells and explores potential mechanisms that underlie early\u2010life immune programming. Specifically, we include a summary of human and animal studies on the placenta and umbilical cord blood in the context of the inflammatory milieu of maternal obesity, with special emphasis on the phenotypes, functions and epigenetic changes in fetal myeloid cells and their haematopoietic progenitors. Key findings suggest that maternal obesity may induce fetal programming of immune\u2010training\u2010like effects in myeloid cells from early stages of fetal life, resulting in a blunted postnatal immune response. This novel perspective highlights the potential short\u2010 and long\u2010term immunological consequences of maternal obesity on offspring, underscoring the critical need for interventions targeting the health of women of childbearing age to prevent acute and chronic immune\u2010related conditions in future generations.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70008-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp285929","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T11:54:55Z","timestamp":1754308495000},"page":"4318-4337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal obesity alters myeloid immune function in the offspring"],"prefix":"10.1113","volume":"604","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-2910","authenticated-orcid":false,"given":"Macarena","family":"L\u00e9pez","sequence":"first","affiliation":[{"name":"PhD Program in Medical Sciences, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Department of Medical Technology, Faculty of Medicine Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Giacaman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Department of Neonatology, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2505-6862","authenticated-orcid":false,"given":"Jorge","family":"G\u00f3mez\u2010Cayup\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Medicine Universidad de Chile  Santiago Chile"},{"name":"Department of Neonatology, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-1476","authenticated-orcid":false,"given":"Paola","family":"Casanello","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Department of Neonatology, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_2_2_1","volume-title":"Cellular and molecular immunology","author":"Abbas A. 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