{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:57:37Z","timestamp":1791565057377,"version":"4.3.4"},"reference-count":100,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["K131893"],"award-info":[{"award-number":["K131893"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["2017\u20101.2.1\u2010NKP\u20102017\u201000002"],"award-info":[{"award-number":["2017\u20101.2.1\u2010NKP\u20102017\u201000002"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Basket cells are inhibitory interneurons in cortical structures with the potential to efficiently control the activity of their postsynaptic partners. Although their contribution to higher order cognitive functions associated with the medial prefrontal cortex (mPFC) relies on the characteristics of their synaptic connections, the way that they are embedded into local circuits is still not fully uncovered. Here, we determined the synaptic properties of excitatory and inhibitory connections between pyramidal neurons (PNs), cholecystokinin\u2010containing basket cells (CCKBCs) and parvalbumin\u2010containing basket cells (PVBCs) in the mouse mPFC. By performing paired recordings, we revealed that PVBCs receive larger unitary excitatory postsynaptic currents from PNs with shorter latency and faster kinetic properties compared to events evoked in CCKBCs. Also, unitary inhibitory postsynaptic currents in PNs were more reliably evoked by PVBCs than by CCKBCs, yet the former connections showed profound short\u2010term depression. Moreover, we demonstrated that CCKBCs and PVBCs in the mPFC are connected with each other. Because alterations in PVBC function have been linked to neurological and psychiatric conditions such as Alzheimer's disease and schizophrenia and CCKBC vulnerability might play a role in mood disorders, a deeper understanding of the general features of basket cell synapses could serve as a reference point for future investigations with therapeutic objectives.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16340-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Cholecystokinin\u2010 (CCKBCs) and parvalbumin\u2010expressing basket cells (PVBCs) have distinct passive and active membrane properties.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Pyramidal neurons give rise to larger unitary excitatory postsynaptic currents in PVBCs compared to events in CCKBCs.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Unitary inhibitory postsynaptic currents in pyramidal neurons are more reliably evoked by PVBCs than by CCKBCs.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Basket cells form chemical synapses and gap junctions with their own cell type.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The two basket cell types are connected with each other.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp286284","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T13:38:20Z","timestamp":1729172300000},"page":"6423-6444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex"],"prefix":"10.1113","volume":"603","author":[{"given":"Zsuzsanna","family":"Fekete","sequence":"first","affiliation":[{"name":"Institute of Experimental Medicine  Budapest Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai School of Neurosciences Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-3896","authenticated-orcid":false,"given":"Filippo","family":"Weisz","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria Rita","family":"Karl\u00f3cai","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit M.","family":"Veres","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Andr\u00e1si","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-2708","authenticated-orcid":false,"given":"Norbert","family":"H\u00e1jos","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine  Budapest Hungary"},{"name":"The Linda and Jack Gill Center for Molecular Bioscience Indiana University Bloomington  Indiana USA"},{"name":"Program in Neuroscience, Department of Psychological and Brain Sciences Indiana University Bloomington  Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0354-y"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.09.035"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.201bu.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2001421"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.223669"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13498"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-08-02687.2001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192233099"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/78809"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00043-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.022"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0442-05.2005"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb00721.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150444"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08002"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5040-09.2010"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00165"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/378075a0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.041"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5760-08.2009"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00272.2012"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.01.003"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/28179"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.09.012"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.031"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4076-05.2006"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm253"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/2822"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/47029"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/47035"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.152"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1688"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.03.010"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00787.2004"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270818"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-22-10082.1999"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00240.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4104-10.2010"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.064"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00217.x"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1996)6:3<306::AID-HIPO8>3.0.CO;2-K"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-15-06315.2003"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1542"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2010.00018"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02168-y"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2255-12.2013"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.05.029"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255263"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.02.024"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2011.00017"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67468"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5264-08.2009"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4814-03.2004"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-23-09506.2001"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-11-04544.1999"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00685-4"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-17-06963.1998"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18426"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.023"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902410202"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272231"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111202"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07919"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.08.010"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1970-11.2011"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4624"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-3-00091.x"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1552-7"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03225.x"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-16-07055.2002"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80101-4"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3325-16.2017"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0432-23.2023"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10118"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3446"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.263889"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02615"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/1092"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0323-19.2020"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01892-0"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00106.x"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0867-14.2014"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01435-w"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07991"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(83)90133-1"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.06.023"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05824.2001"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07292.x"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/73936"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp022054"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.033"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2570"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2700-20.2021"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20721"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.4.395"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00372-5"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/35069076"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00739.2007"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.64.092501.114547"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP286284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP286284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP286284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:15:20Z","timestamp":1773119720000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP286284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":100,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1113\/JP286284"],"URL":"https:\/\/doi.org\/10.1113\/jp286284","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.01.16.575904","asserted-by":"object"}]},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]},"assertion":[{"value":"2024-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}