{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:41:38Z","timestamp":1788543698556,"version":"build-2803163510"},"reference-count":78,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:italic>In utero<\/jats:italic> nicotine exposure from maternal smoking is linked to increased risk of auditory processing deficits. This study investigated the impact of developmental nicotine exposure during the critical period on nicotinic acetylcholine receptor (nAChR) functional expression, glutamatergic synaptic transmission and auditory processing in the mouse auditory brainstem. We assessed nAChR function at a central synapse and the consequences of perinatal nicotine exposure (PNE) on synaptic currents and auditory brainstem responses (ABRs) in mice. Our results indicate developmentally regulated changes in nAChR expression in medial nucleus of the trapezoid body (MNTB) neurons and presynaptic calyx of Held terminals. PNE led to increased ACh\u2010evoked postsynaptic currents and impaired glutamatergic neurotransmission, underscoring the importance of nAChR activity in early auditory synaptic development. PNE also increased ABR thresholds and reduced ABR peak amplitudes, indicating impaired central auditory processing without cochlear dysfunction. Our study provides new insights into the synaptic disruptions underlying auditory deficits from prenatal nicotine exposure.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16695-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:italic>In utero<\/jats:italic> nicotine exposure leads to increased risk of sensory processing deficits and elevated expression of nicotinic acetylcholine receptors (nAChRs).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>nAChRs are essential for auditory processing and are present in the auditory brainstem.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Within the medial nucleus of the trapezoid body in the auditory brainstem, the patterning of nicotinic receptor expression during development and how nicotine exposure might affect this are unknown.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Nicotinic receptors are expressed postsynaptically before hearing onset and switch to presynaptic expression after hearing onset.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Perinatal nicotine exposure disrupts physiological nicotinic receptor patterning and impairs synaptic transmission at the calyx of Held.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp286971","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T07:25:48Z","timestamp":1746429948000},"page":"2857-2876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impacts of perinatal nicotine exposure on nicotinic acetylcholine receptor expression and glutamatergic synaptic transmission in the mouse auditory brainstem"],"prefix":"10.1113","volume":"603","author":[{"given":"Mackenna","family":"Wollet","sequence":"first","affiliation":[{"name":"Department of Cellular and Integrative Physiology UT Health San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abram","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology UT Health San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaila","family":"Nip","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology UT Health San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Ginsburg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Science UT Health San Antonio  San Antonio Texas 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