{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:40:33Z","timestamp":1789065633443,"version":"build-2803163510"},"reference-count":350,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["#417022"],"award-info":[{"award-number":["#417022"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["#526912"],"award-info":[{"award-number":["#526912"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["FRQS\u2010297877"],"award-info":[{"award-number":["FRQS\u2010297877"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102021\u201003724"],"award-info":[{"award-number":["RGPIN\u20102021\u201003724"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mitochondria are dynamic and multifunctional organelles central to cellular bioenergetics and metabolism and acting as vital signalling hubs. Their morphology is finely regulated by the opposing processes of fusion and fission, predominantly controlled by four key GTPases: mitofusin 1 (MFN1), mitofusin 2 (MFN2), optic atrophy 1 (OPA1)\u00a0and dynamin\u2010related protein 1 (DRP1). In humans, mutations in their genes are linked to a broad range of pathological disorders. In animal models, both loss\u2010 and gain\u2010of\u2010function manipulations of these proteins lead to diverse physiological outcomes. Recent research has uncovered that, beyond their canonical roles in shaping mitochondrial morphology, these GTPases also participate in a variety of non\u2010canonical cellular functions, impacting broader aspects of cell physiology. In this review, we examine the established functions of these GTPases in mitochondrial dynamics alongside their emerging roles beyond shaping mitochondrial morphology. We also provide an in\u2010depth overview of how alterations in their expression or activity influence mammalian health and physiology. By highlighting the multifaceted roles and broad physiological impact of mitochondrial fusion and fission proteins, we aim to underscore their complex biology and promote further investigation into their broader physiological significance.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70228-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp287149","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T16:04:59Z","timestamp":1763827499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Canonical and non\u2010canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology"],"prefix":"10.1113","author":[{"given":"R\u00e9mi","family":"Chaney","sequence":"first","affiliation":[{"name":"D\u00e9partement des sciences de l'activit\u00e9 physique Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Groupe de recherche en Activit\u00e9 Physique Adapt\u00e9e  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Marcangeli","sequence":"additional","affiliation":[{"name":"D\u00e9partement des sciences de l'activit\u00e9 physique Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Groupe de recherche en Activit\u00e9 Physique Adapt\u00e9e  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement des sciences biologiques Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8451-0600","authenticated-orcid":false,"given":"Krystel","family":"Desjardins","sequence":"additional","affiliation":[{"name":"D\u00e9partement des sciences de l'activit\u00e9 physique Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Groupe de recherche en Activit\u00e9 Physique Adapt\u00e9e  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-9047","authenticated-orcid":false,"given":"Shima","family":"Taherkhani","sequence":"additional","affiliation":[{"name":"D\u00e9partement des sciences de l'activit\u00e9 physique Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Groupe de recherche en Activit\u00e9 Physique Adapt\u00e9e  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement des sciences biologiques Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-3619","authenticated-orcid":false,"given":"Gilles","family":"Gouspillou","sequence":"additional","affiliation":[{"name":"D\u00e9partement des sciences de l'activit\u00e9 physique Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Groupe de recherche en Activit\u00e9 Physique Adapt\u00e9e  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al  Qu\u00e9bec Canada"},{"name":"Meakins\u2010Christie Laboratories and Department of Critical Care Medicine McGill University  Montreal Quebec 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