{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:18:15Z","timestamp":1773047895978,"version":"3.50.1"},"reference-count":78,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>Programming effects of maternal undernutrition on fetal metabolic and cardiovascular systems are well elucidated, yet a detailed characterization of maternal haemodynamics is not available. This study used comprehensive cardiovascular magnetic resonance (CMR) imaging to quantify maternal haemodynamics after 29\u00a0days (111\u2013140 days) of late\u2010gestation undernutrition (LGUN) in pregnant sheep. Control ewes received 100% of metabolizable energy requirements (MERs, <jats:italic>n<\/jats:italic>\u00a0=\u00a015), whereas LGUN ewes were globally nutrient restricted to 50% MER (<jats:italic>n<\/jats:italic>\u00a0=\u00a018), with a subset of fetuses undergoing continuous glucose infusion (LGUN\u00a0+\u00a0G, <jats:italic>n<\/jats:italic>\u00a0=\u00a06\/18). Ewes underwent CMR (138\u2013140 days\u2019 gestation), and placental tissue was collected the next day. Ewes in both LGUN groups had reduced body weight and mean blood glucose concentration across gestation. Ventricular dimensions were lower in both LGUN groups. Uterine artery blood flow (QUtA) was elevated in the LGUN group compared with controls, whereas peripheral blood flow was reduced and further diminished in LGUN\u00a0+\u00a0G. Maternal weight change correlated with all haemodynamic parameters across all groups. Uteroplacental oxygen and glucose delivery were increased in LGUN compared to control ewes, whereas uteroplacental oxygen consumption was preserved. LGUN did not impact placental or fetal weight, and markers of brain\u2010sparing physiology were absent. Placental expression of insulin\u2010like growth factors (IGF\u20101 and IGF\u20102) and their receptors, glucose, fatty acid (FA) or amino acid transporters and markers of angiogenesis was not impacted. FA transporter expression was positively correlated with QUtA, and FA binding protein correlated negatively with maternal weight change. Maternal cardiovascular adaptations in response to LGUN manifest as preservation of placental growth and function, thereby preserving fetal growth.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16400-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Maternal undernutrition during pregnancy alters fetal metabolic and cardiovascular physiology, but little is known about alterations in maternal haemodynamics.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Late\u2010gestation undernutrition (LGUN) and LGUN\u00a0+\u00a0G redirected maternal blood flow from the periphery to the uteroplacental unit, concomitantly increasing the delivery of glucose and oxygen to the uteroplacental unit.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Substrate transporter expression and uteroplacental oxygen consumption were preserved in LGUN and LGUN\u00a0+\u00a0G, suggesting prioritization of the placenta.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This study is the first to report detailed maternal haemodynamics in the setting of maternal undernutrition, where placental growth and function were maintained, ultimately preserving fetal oxygen metabolism and growth.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp287171","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T22:34:18Z","timestamp":1731796458000},"page":"7065-7083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Late\u2010gestation maternal undernutrition induces circulatory redistribution while preserving 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