{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:03:03Z","timestamp":1791856983682,"version":"4.3.4"},"reference-count":80,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n Abstract<\/jats:title>\n \n The neurogenic potential of the brain decreases during ageing, whereas the risk of neurodegenerative diseases and stroke rises. This creates a mismatch between the rate of neuron loss and the brain's capacity for replacement. Adult neurogenesis primarily occurs in the subgranular zone (SGZ) and the ventricular\u2010subventricular zone (V\u2010SVZ). Exercise enhances SGZ neurogenesis, and we previously showed that V\u2010SVZ neurogenesis is induced by exercise via activation of the lactate receptor HCA\n 1<\/jats:sub>\n . Here, we investigated how high\u2010intensity interval training (HIIT) and medium\u2010intensity interval training (MIIT) affect neurogenesis in these niches. Wild\u2010type (WT) and HCA\n 1<\/jats:sub>\n knockout (KO) mice were randomized to sedentary, HIIT or MIIT (\n n<\/jats:italic>\n \u00a0=\u00a05\u20138 per group) for 3 weeks. In the SGZ, HIIT increased the density of doublecortin (DCX)\u2010positive cells in WT mice by 85% (5.77\u00b11.76\n vs<\/jats:italic>\n . 3.12\u00b11.54\u00a0cells\/100\u00a0\u00b5m,\n P<\/jats:italic>\n \u00a0=\u00a00.013) and KO mice (67% increase; 7.91\u00b12.92\n vs<\/jats:italic>\n . 4.73\u00b11.63\u00a0cells\/100\u00a0\u00b5m,\n P<\/jats:italic>\n \u00a0=\u00a00.004). MIIT did not alter the density of DCX\u2010positive cells in either genotype. HIIT increased the density of Ki\u201067\u2010positive cells only in KO mice (\n P<\/jats:italic>\n \u00a0=\u00a00.038), whereas no differences in nestin\u2010positive cells were observed. In the V\u2010SVZ, HIIT increased the density of DCX\u2010positive cells in WT mice by 155% (117.79\u00b139.72\n vs<\/jats:italic>\n . 46.25\u00b119.96\u00a0cells\/100\u00a0\u00b5m,\n P\u00a0<\/jats:italic>\n <\u00a00.001) and MIIT increased the density of DCX\u2010positive cells by 80% (83.26\u00b139.48\n vs<\/jats:italic>\n . 46.25\u00b119.96\u00a0cells\/100\u00b5m,\n P<\/jats:italic>\n \u00a0=\u00a00.027). No exercise\u2010induced changes were observed in KO mice. Similar patterns were noted for Ki\u201067 positive and DCX\/Ki\u201067 double\u2010positive cells in the V\u2010SVZ. These findings suggest that HIIT enhances neurogenesis more robustly than MIIT in both niches, with HCA\n 1<\/jats:sub>\n playing a crucial role in V\u2010SVZ neurogenesis.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n The neurogenic potential of the brain decreases with age, whereas the risk of neurodegenerative diseases and stroke increases, highlighting a mismatch between neuronal loss and replacement capacity.<\/jats:p>\n <\/jats:list-item>\n \n Exercise enhances neurogenesis in both the subgranular zone and the ventricular\u2010subventricular zone.<\/jats:p>\n <\/jats:list-item>\n \n High\u2010intensity interval exercise is more effective than medium\u2010intensity interval exercise at promoting neurogenesis in both the subgranular zone and the ventricular\u2010subventricular zone of wild\u2010type mice.<\/jats:p>\n <\/jats:list-item>\n \n \n The enhancement of neurogenesis in the ventricular\u2010subventricular zone is dependent on the activation of the HCA\n 1<\/jats:sub>\n receptor, as evidenced by the ability of medium\u2010 and high\u2010intensity interval exercise to induce neurogenesis in wild\u2010type mice and the lack of this effect in HCA\n 1<\/jats:sub>\n knockout mice.\n <\/jats:p>\n <\/jats:list-item>\n \n \n By contrast, neurogenesis in the subgranular zone is independent on the activation of the HCA\n 1<\/jats:sub>\n receptor, highlighting that neurogenesis in the two major neurogenic niches are regulated differently.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1113\/jp287328","type":"journal-article","created":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:39:12Z","timestamp":1732408752000},"page":"7027-7042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["High\u2010intensity interval exercise is more efficient than medium intensity exercise at inducing neurogenesis"],"prefix":"10.1113","volume":"602","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5809-9291","authenticated-orcid":false,"given":"Marvin","family":"Lambertus","sequence":"first","affiliation":[{"name":"Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1332-3816","authenticated-orcid":false,"given":"Samuel","family":"Geiseler","sequence":"additional","affiliation":[{"name":"Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-1821","authenticated-orcid":false,"given":"Cecilie","family":"Morland","sequence":"additional","affiliation":[{"name":"Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy 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