{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:27:22Z","timestamp":1791923242657,"version":"4.3.4"},"reference-count":127,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/X010511\/1"],"award-info":[{"award-number":["MR\/X010511\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pericytes are mural cells of the microvasculature, characterised by a distinctive \u2018bump\u2010on\u2010a\u2010log\u2019 morphology and elongated processes extending along the abluminal surface of capillary and pre\u2010 and post\u2010capillary segments. They are widely distributed across organs and exhibit functional heterogeneity. Contractile pericytes directly regulate local blood flow, whereas non\u2010contractile pericytes contribute to electrical signalling by generating depolarising or hyperpolarising events that propagate to upstream vessels and coordinate tissue perfusion. These functions are closely linked to intracellular ion homeostasis. Recent evidence highlights a role for Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010activated Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    channels (CaCCs), particularly TMEM16A (ANO1), in coupling intracellular Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    signals to membrane depolarisation and pericyte activity. In contractile pericytes, TMEM16A\u2010mediated currents promote depolarisation to activate L\u2010type voltage\u2010gated Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    channels, facilitating Ca\n                    <jats:sup>2+<\/jats:sup>\n                    entry to support contraction. In non\u2010contractile capillary pericytes, periodically generated TMEM16A\u2010dependent depolarisations contribute to the initiation and propagation of spontaneous electrical activity, supporting intercellular synchrony within microvascular networks. Alternatively, asynchronous TMEM16A\u2010dependent depolarisations could sum with each other to maintain resting membrane potentials and basal vascular tone. In this review, we summarise current understanding of CaCC channel function in pericytes across organs, and discuss emerging directions for future research and therapeutic targeting.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70557-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp287607","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:54:56Z","timestamp":1778205296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Calcium\u2010activated chloride channels in pericytes and their role in regulating organ blood flow"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-8187","authenticated-orcid":false,"given":"Paolo","family":"Tammaro","sequence":"first","affiliation":[{"name":"Department of Pharmacology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-4349","authenticated-orcid":false,"given":"Hikaru","family":"Hashitani","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology Graduate School of Medical Sciences Nagoya City University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"issue":"3","key":"e_1_2_2_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031580","article-title":"Polymodal control of TMEM16x channels and scramblases","volume":"23","author":"Agostinelli E.","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_2_3_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1113\/jphysiol.1982.sp014182","article-title":"Measurement of intracellular chloride in guinea\u2010pig vas deferens by ion analysis, 36chloride efflux and micro\u2010electrodes","volume":"326","author":"Aickin C. 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