{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:24:20Z","timestamp":1790666660449,"version":"4.1.0"},"reference-count":103,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["860034"],"award-info":[{"award-number":["860034"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mammalian ageing is defined as a gradual loss of the capacity to maintain tissue homeostasis or to repair tissues after injury or stress. Cellular senescence is induced by various cellular stressors, and there is accumulation of senescent cells in all tissues with ageing and chronic disease, which contributes to pathophysiology and organ deterioration. Long\u2010term persistence of senescent cells and their senescence\u2010associated secretory phenotype (SASP) impairs tissue homeostasis and regenerative capacity, leading to tissue and physiological dysfunction. Senolytics are senotherapeutic agents that systemically eliminate senescent cells, and have been shown in pre\u2010clinical and clinical studies to improve cardiac and skeletal muscle regeneration, remodelling and physiological function. Exercise training and physical activity have also been shown to have senolytic effects. In this review, we evaluate whether targeting cell senescence using senolytics can rejuvenate the heart and skeletal muscle, reversing the ageing phenotype.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70410-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp287702","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:26:33Z","timestamp":1773030393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Senolytics and exercise: Dual modalities for rejuvenating muscle"],"prefix":"10.1113","author":[{"given":"Zeynep Elif","family":"Yesilyurt\u2010Dirican","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy Gazi University  Ankara T\u00fcrkiye"},{"name":"School of Basic and Medical Biosciences, Faculty of Life Sciences &amp; Medicine, Guy's Campus King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Basic and Medical Biosciences, Faculty of Life Sciences &amp; Medicine, Guy's Campus King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchenna","family":"Okpechi","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences &amp; Medicine, King's College London St Thomas\u2019 Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Strand Ford","sequence":"additional","affiliation":[{"name":"School of Basic and Medical Biosciences, Faculty of Life Sciences &amp; Medicine, Guy's Campus King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina M.","family":"Ellison\u2010Hughes","sequence":"additional","affiliation":[{"name":"School of Basic and Medical Biosciences, Faculty of Life Sciences &amp; Medicine, Guy's Campus King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.111212"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100492"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00799.2015"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16932"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10600"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP284128"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1452"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0314-9"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-023-01657-z"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4010"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000093985.76901.AF"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39663-3"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12848"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.741542"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0241"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13249"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00816.2024"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13528"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000111RR"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00553.2022"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1798403"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101652"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03096-2"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00685-2"},{"issue":"2","key":"e_1_2_3_26_1","first-page":"226","article-title":"Human primary skeletal muscle\u2010derived myoblasts and fibroblasts reveal different senescent phenotypes","volume":"5","author":"Francis T. G.","year":"2022","journal-title":"Journal of Cachexia, Sarcopenia and Muscle\u2010Rapid Communications"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00314-z"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16187"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.005"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0122-z"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP092331"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-023-00869-4"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400137"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00029.2016"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.08.069"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101528"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.902221"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13112"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18039-x"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204511"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205827"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000878"},{"key":"e_1_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.12.052"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.04.013"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14969"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.07.022"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.645593"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00186-2"},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106356"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12931"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.12.017"},{"key":"e_1_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.19-131"},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204275"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00358.x"},{"key":"e_1_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.20517\/jca.2024.31"},{"key":"e_1_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14060"},{"key":"e_1_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0536"},{"key":"e_1_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2023.100676"},{"key":"e_1_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.04.007"},{"key":"e_1_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00624-2"},{"key":"e_1_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05535-x"},{"key":"e_1_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3823"},{"key":"e_1_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70108"},{"key":"e_1_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104481"},{"key":"e_1_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00177.2021"},{"key":"e_1_2_3_66_1","first-page":"9393","article-title":"Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence","volume":"14","author":"Perez K.","year":"2022","journal-title":"Aging"},{"key":"e_1_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13936"},{"key":"e_1_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2025.102130"},{"key":"e_1_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101807"},{"key":"e_1_2_3_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.902056"},{"issue":"5","key":"e_1_2_3_71_1","first-page":"533","article-title":"Noninvasive techniques for tracking biological aging of the cardiovascular system: JACC family series","volume":"17","author":"Raisi\u2010Estabragh Z.","year":"2024","journal-title":"Journal of the American College of Cardiology Cardiovasc Imaging"},{"key":"e_1_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-318654"},{"key":"e_1_2_3_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00416.2017"},{"key":"e_1_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.739510"},{"key":"e_1_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2022.111740"},{"key":"e_1_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033675"},{"key":"e_1_2_3_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00360-x"},{"key":"e_1_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.624028"},{"key":"e_1_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13013"},{"key":"e_1_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-23-0657"},{"key":"e_1_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73315-6"},{"key":"e_1_2_3_82_1","first-page":"21","article-title":"Senolytics rejuvenate the reparative activity of human cardiomyocytes and endothelial cells","volume":"3","author":"Sunderland P.","year":"2023","journal-title":"The Journal of Cardiovascular Aging"},{"key":"e_1_2_3_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.74"},{"key":"e_1_2_3_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2024.111995"},{"key":"e_1_2_3_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.12440"},{"key":"e_1_2_3_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12888-x"},{"key":"e_1_2_3_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111548"},{"key":"e_1_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3428"},{"key":"e_1_2_3_89_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140051"},{"key":"e_1_2_3_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade4961"},{"key":"e_1_2_3_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12945"},{"key":"e_1_2_3_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13106"},{"key":"e_1_2_3_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2009.00481.x"},{"key":"e_1_2_3_94_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306596"},{"key":"e_1_2_3_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0092-9"},{"issue":"1","key":"e_1_2_3_96_1","first-page":"35","article-title":"SGLT2 inhibitors as a novel senotherapeutic approach","volume":"11","author":"Yesilyurt\u2010Dirican Z. E.","year":"2025","journal-title":"Nature Partner Journals Aging"},{"key":"e_1_2_3_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00397.2020"},{"key":"e_1_2_3_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13094"},{"key":"e_1_2_3_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.09.015"},{"key":"e_1_2_3_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16350"},{"key":"e_1_2_3_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00250-8"},{"key":"e_1_2_3_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14069"},{"key":"e_1_2_3_103_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101202"},{"key":"e_1_2_3_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12344"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP287702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP287702","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP287702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:26:36Z","timestamp":1773030396000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP287702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":103,"alternative-id":["10.1113\/JP287702"],"URL":"https:\/\/doi.org\/10.1113\/jp287702","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"2025-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"JP287702"}}