{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:28:34Z","timestamp":1785446914893,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["898649"],"award-info":[{"award-number":["898649"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>Menopause is associated with vascular dysfunction. During the menopausal transition, endogenous oestradiol concentrations diminish. Oestradiol is vasoprotective because it has direct and indirect effects on the vasculature. The present study aimed to determine the effect of acute exogenous oestradiol on endothelium\u2010dependent, endothelium independent and \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic receptor\u2010induced vasodilatation in females. Forearm blood flow (venous occlusion plethysmography) was measured during brachial intraarterial infusions of ACh (endothelium\u2010dependent agonist), sodium nitroprusside (endothelium independent agonist) and terbutaline (\u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic receptor agonist) with and without concurrent infusion of 17\u03b2\u2010oestradiol. Nine young premenopausal (age: 26\u00a0\u00b1\u00a04\u00a0years) and nine postmenopausal (PM, age: 58\u00a0\u00b1\u00a04\u00a0years, 8\u00a0\u00b1\u00a01\u00a0years post\u2010menopause) females completed the study. Concurrent oestradiol infusion augmented the vasodilatory response to ACh, sodium nitroprusside and terbutaline in young premenopausal (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) but not older postmenopausal (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05), females. Local infusion of exogenous 17\u03b2\u2010oestradiol augmented endothelial and smooth muscle microvascular vasodilatation in premenopausal but not postmenopausal, females.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16588-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Menopause is associated with vascular dysfunction.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Because oestradiol has vasoprotective effects, the menopause\u2010associated drop in oestradiol concentrations is hypothesized to contribute to vascular dysfunction during the menopause transition.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The present study shows that local infusion of exogenous oestradiol augmented microvascular vasodilatation in premenopausal but not postmenopausal females.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp287719","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:48:05Z","timestamp":1741733285000},"page":"2301-2311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute exogenous oestradiol augments endothelial and smooth muscle vasodilatory responsiveness in premenopausal but not postmenopausal females"],"prefix":"10.1113","volume":"603","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5365-2852","authenticated-orcid":false,"given":"Gabrielle A.","family":"Dillon","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester MN USA"},{"name":"Department of Health and Kinesiology University of 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