{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:56:08Z","timestamp":1783785368864,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>Despite reports of amplified carotid chemoreflex sensitivity to hypoxia in young adults with hypertension (&lt;40\u00a0years), it is unclear whether this equates to a direct role of this reflex in maintaining high resting and exercise blood pressures (BP). The aim of this study was to examine whether tonic carotid chemoreflex activity contributes to high resting and exercise BP in young people with untreated hypertension compared to normotensives (NTN). In 14 NTN and 14 untreated hypertensives (HTN) (aged 27\u00a0\u00b1\u00a06 and 28\u00a0\u00b1\u00a05\u00a0years, respectively) the ventilatory and haemodynamic responses to hypoxia were measured using the transient hypoxic test at rest and during submaximal steady\u2010state upright cycle exercise (40%\u201350% ). A double\u2010blinded placebo\u2010controlled systemic infusion of low\u2010dose dopamine (2\u00a0mcg\/kg\/min) was used to inhibit the carotid chemoreflex and assess its tonic contribution to ventilation and BP at rest and submaximal exercise (mixed\u2010model ANOVA). The hypoxic ventilatory response (HVR) at rest and submaximal cycle exercise were comparable between groups and were similarly blunted by dopamine infusion in both groups. However, at rest, there was a greater decrease in resting systolic BP (SBP) during carotid chemoreflex inhibition in the HTN group. Notably, during submaximal exercise, SBP was reduced during dopamine <jats:italic>versus<\/jats:italic> that during saline, but the decrease was similar between groups. The carotid chemoreflex appears to contribute to resting SBP in young people with untreated HTN but does not play a role in exaggerated exercise BP responses in this group.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16592-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The role of the carotid chemoreflex in maintaining high resting and exercise blood pressures in young adults with untreated hypertension is unclear.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Carotid chemoreflex sensitivity, assessed by the ventilatory response to hypoxia was similar between untreated young adults with hypertension (<jats:italic>n<\/jats:italic>\u00a0=\u00a014, age\u00a0&lt;\u00a040\u00a0years) and age\u2010matched normotensives (<jats:italic>n<\/jats:italic>\u00a0=\u00a014).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>During normoxic rest, there was a reduction in SBP during carotid chemoreflex inhibition with low\u2010dose dopamine (2\u00a0mcg\/kg\/min; <jats:italic>vs<\/jats:italic>. saline) in people with hypertension which was not observed in the normotensive group.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>During submaximal cycle exercise, SBP was reduced during carotid chemoreflex inhibition, but this was similar between groups.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest the carotid chemoreflex influences resting SBP in hypertensives but does not affect the exaggerated exercise BP response in this group.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp287743","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T22:05:54Z","timestamp":1743458754000},"page":"2313-2332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Carotid chemoreflex control of blood pressure at rest and during exercise in young\u2010onset hypertension"],"prefix":"10.1113","volume":"603","author":[{"given":"Thomas","family":"Hinton","sequence":"first","affiliation":[{"name":"School of Physiology, Pharmacology and Neuroscience University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Hope","sequence":"additional","affiliation":[{"name":"School of Physiology, Pharmacology and Neuroscience University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-0123","authenticated-orcid":false,"given":"Zoe","family":"Adams","sequence":"additional","affiliation":[{"name":"School of Physiology, Pharmacology and Neuroscience University of Bristol  Bristol UK"},{"name":"Cardiff School of Sport and Health Sciences Cardiff Metropolitan University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"School of Physiology, Pharmacology and Neuroscience University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-2913","authenticated-orcid":false,"given":"Julian F. 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