{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:12:21Z","timestamp":1790053941248,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH017\u20101\u20100660"],"award-info":[{"award-number":["W81XWH017\u20101\u20100660"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Health Research BC","doi-asserted-by":"publisher","award":["Trainee Award #17\u00a0197"],"award-info":[{"award-number":["Trainee Award #17\u00a0197"]}],"id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"\n Abstract<\/jats:title>\n \n Chronic high\u2010level spinal cord injury (SCI) leads to a complex phenotype of long\u2010term cardio\u2010autonomic dysregulation. In the initial hours post\u2010injury, cardio\u2010centric management with dobutamine (DOB) can optimize cardiovascular haemodynamics and mitigate secondary injury compared with standard vasopressor\u2010based management (i.e. norepinephrine, NE) in a porcine model of T2 SCI; however, any potential long\u2010term benefits remain to be determined. We therefore sought to assess whether acute DOB treatment could mitigate cardiovascular dysfunction in the chronic setting of high\u2010level SCI. Seventeen Yucatan minipigs with T2 SCI received acute management with DOB (2.5\u00a0\u00b5g\u00a0kg\n \u2212<\/jats:sup>\n 1\u00a0min\n \u22121<\/jats:sup>\n ,\n n\u00a0=\u00a06<\/jats:italic>\n ), NE (4.25\u00a0\u00b5g\u00a0kg\n \u22121<\/jats:sup>\n \u00a0min\n \u22121<\/jats:sup>\n ,\n n\u00a0=\u00a06<\/jats:italic>\n ) or no management (CON,\n n\u00a0=\u00a05<\/jats:italic>\n ) from 30\u00a0min until 6\u00a0h post\u2010SCI, then were recovered and housed for 12\u00a0weeks. Outcome assessments were performed at 12\u00a0weeks post\u2010SCI, including left ventricular (LV), Swan\u2010Ganz and arterial catheterization to characterize cardiac and peripheral haemodynamics. Resting mean arterial pressure (MAP) was higher in both treatment groups (DOB:80\u00a0\u00b1\u00a09\u00a0mmHg, NE:88\u00a0\u00b1\u00a011\u00a0mmHg\n vs<\/jats:italic>\n . CON:65\u00a0\u00b1\u00a03\u00a0mmHg;\n P<\/jats:italic>\n \u00a0=\u00a00.0147 for DOB,\n P<\/jats:italic>\n \u00a0=\u00a00.00679 for NE), and DOB\u2010treated animals had greater stroke volume (33\u00a0\u00b1\u00a04\u00a0ml\n vs<\/jats:italic>\n . NE:25\u00a0\u00b1\u00a05\u00a0ml,\n P<\/jats:italic>\n \u00a0=\u00a00.0269), while NE\u2010treated animals had elevated total peripheral resistance (41\u00a0\u00b1\u00a011\u00a0mmHg\u00a0l\n \u22121<\/jats:sup>\n \u00a0min\n \u22121<\/jats:sup>\n vs<\/jats:italic>\n . CON:24\u00a0\u00b1\u00a04\u00a0mmHg\u00a0l\n \u22121<\/jats:sup>\n \u00a0min\n \u22121<\/jats:sup>\n ,\n P<\/jats:italic>\n \u00a0=\u00a00.0345) and arterial elastance (3.60\u00a0\u00b1\u00a00.95\u00a0mmHg\u00a0ml\n \u22121<\/jats:sup>\n vs<\/jats:italic>\n . CON:2.08\u00a0\u00b1\u00a00.34\u00a0mmHg\u00a0ml\n \u22121<\/jats:sup>\n ,\n P<\/jats:italic>\n \u00a0=\u00a00.0258\n vs<\/jats:italic>\n . CON). Dynamic LV function was also preserved in DOB\u2010treated animals, with greater contractile responses during the DOB stress test (end\u2010systolic elastance; +8.96\u00a0mmHg\u00a0ml\n \u22121<\/jats:sup>\n vs<\/jats:italic>\n . CON:+1.28\u00a0mmHg\u00a0ml\n \u22121<\/jats:sup>\n ,\n P<\/jats:italic>\n \u00a0=\u00a00.036) and modified Oxford challenges (preload\u2010adjusted maximal rate of pressure development (dp\/dt\n max<\/jats:sub>\n \u2010EDV)\n vs<\/jats:italic>\n . MAP; \u20100.56\u00a0\u00b1\u00a00.33\u00a0ml\u00a0s\n \u22121<\/jats:sup>\n vs<\/jats:italic>\n . CON:0.04\u00a0\u00b1\u00a00.05\u00a0mls\n \u22121<\/jats:sup>\n ,\n P<\/jats:italic>\n \u00a0=\u00a00.044). Collectively, these findings demonstrate that acute cardio\u2010centric management with DOB provides a viable alternative for haemodynamic management following high\u2010thoracic SCI.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n Spinal cord injuries (SCIs) at or above the mid\u2010thoracic level lead to long\u2010term heart and circulatory complications.<\/jats:p>\n <\/jats:list-item>\n \n This research primarily sought to understand whether a heart\u2010focused treatment (dobutamine, DOB) could support long\u2010term cardiovascular benefits when compared with current standard treatments (norepinephrine, NE) in a pig model with a high\u2010thoracic SCI.<\/jats:p>\n <\/jats:list-item>\n \n Treatments were administered from 30\u00a0min to 6\u00a0h post\u2010injury, and after 12\u00a0weeks\u2019 survival both DOB and NE animals had improved blood pressure. However, the DOB group additionally had preserved reflexive heart function when compared with control animals.<\/jats:p>\n <\/jats:list-item>\n \n Animals treated with DOB also exhibited more white matter sparing at study termination compared with animals treated with NE, implying superior neuroprotection.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1113\/jp288045","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:25:15Z","timestamp":1773404715000},"page":"2659-2682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute cardio\u2010centric haemodynamic management preserves chronic cardiovascular function in pigs with high\u2010thoracic spinal cord injury"],"prefix":"10.1113","volume":"604","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-9168","authenticated-orcid":false,"given":"Alexandra 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