{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:01:56Z","timestamp":1785225716593,"version":"3.55.0"},"reference-count":115,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT170100431"],"award-info":[{"award-number":["FT170100431"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1182242"],"award-info":[{"award-number":["APP1182242"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Placental restriction and models of maternal hypoxia result in fetal growth restriction (FGR) with fetal circulatory redistribution, including increased ductus venosus shunting and brain sparing. In contrast, there are limited reports on the effects of fetal nutrient restriction on circulatory redistribution, with data on acute hypoglycaemic challenges or end\u2010organ weights following chronic nutrient restriction. Fetal cardiovascular magnetic resonance (CMR) was employed to define fetal haemodynamics\n                      <jats:italic>in utero<\/jats:italic>\n                      following 25\u00a0days of maternal late gestation undernutrition (LGUN). Control ewes received 100% metabolizable energy requirements (MER), whereas LGUN and LGUN + intrafetal glucose supplementation (LGUN\u00a0+\u00a0G) ewes received 50% of MER. Fetal CMR was conducted after the dietary regime, and fetal liver was collected the following day. All fetuses were normoxaemic, whereas mean gestational fetal plasma glucose concentrations were lower in both LGUN and LGUN\u00a0+\u00a0G fetuses compared to control. There was a negative relationship between relative brain weight and fetal plasma glucose concentration. Biventricular ejection fraction and ductus venosus shunting were increased in LGUN compared to control but were normalized in LGUN\u00a0+\u00a0G. Relative left liver lobe weight demonstrated a negative linear relationship with fetal glucose, whereas right\u2010lobe weight revealed a positive relationship. Cerebral oxygen delivery was lower in LGUN compared to control, whereas cerebral oxygen consumption (VO\n                      <jats:sub>2<\/jats:sub>\n                      ) was diminished in both LGUN and LGUN + G compared to control. Cerebral VO\n                      <jats:sub>2<\/jats:sub>\n                      correlated positively with fetal glucose. Although intrafetal glucose infusion did not normalize fetal glucose, cardiovascular changes were normalized, providing support for the role of glucose in mediating aspects of FGR physiology in normoxaemic but hypoglycaemic fetuses of LGUN ewes.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70295-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            Maternal late gestation undernutrition (LGUN) can lead to fetal growth restriction (FGR) independent of fetal hypoxaemia, but detailed characterization of fetal haemodynamics\n                            <jats:italic>in utero<\/jats:italic>\n                            is lacking.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>There was a negative relationship between relative brain weight and fetal plasma glucose concentration.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>LGUN increased fetal ventricular ejection fraction and ductus venosus shunting, both of which were normalized in LGUN fetuses that received intrafetal glucose infusion (LGUN + G).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Relationships between left liver lobe sparing and cerebral oxygen consumption (VO\n                            <jats:sub>2<\/jats:sub>\n                            ) and fetal glucose concentrations were observed.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Cerebral VO\n                            <jats:sub>2<\/jats:sub>\n                            was diminished in both LGUN and LGUN + G compared to control.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This study is the first to comprehensively characterize fetal haemodynamics and oxygen consumption in the setting of LGUN and fetal normoxaemia, suggesting the role of fetal plasma glucose concentration in mediating aspects of FGR physiology.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp288413","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T14:30:51Z","timestamp":1767709851000},"page":"2250-2275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal late gestation undernutrition in sheep is associated with increased ductus venosus shunting and reduced cerebral oxygen consumption"],"prefix":"10.1113","volume":"604","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-0192","authenticated-orcid":false,"given":"Steven K. S.","family":"Cho","sequence":"first","affiliation":[{"name":"Translational Medicine The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Division of Cardiology The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Early Origins of Adult Health Research Group, Robinson Research Institute, Adelaide University Adelaide University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-3812","authenticated-orcid":false,"given":"Brahmdeep S.","family":"Saini","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-3920","authenticated-orcid":false,"given":"Jack R. T.","family":"Darby","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Robinson Research Institute, Adelaide University Adelaide University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6326-4797","authenticated-orcid":false,"given":"Stacey L.","family":"Holman","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Robinson Research Institute, Adelaide University Adelaide University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-1455","authenticated-orcid":false,"given":"Mitchell C.","family":"Lock","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Robinson Research Institute, Adelaide University Adelaide University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-1322","authenticated-orcid":false,"given":"Georgia K.","family":"Williams","sequence":"additional","affiliation":[{"name":"Preclinical, Imaging &amp; Research Laboratories South Australian Health &amp; Medical Research Institute  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6565-445X","authenticated-orcid":false,"given":"Raj","family":"Perumal","sequence":"additional","affiliation":[{"name":"Preclinical, Imaging &amp; Research Laboratories South Australian Health &amp; Medical Research Institute  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-0662","authenticated-orcid":false,"given":"Christopher","family":"Macgowan","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, Faculty of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7330-234X","authenticated-orcid":false,"given":"Mike","family":"Seed","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Paediatrics, Faculty of Medicine University of Toronto Toronto Ontario Canada"},{"name":"Department of Physiology, Faculty of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8602-8519","authenticated-orcid":false,"given":"Janna L.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Robinson Research Institute, Adelaide University Adelaide University Adelaide South Australia Australia"},{"name":"Department of Physiology, Faculty of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705849"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(88)90093-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91585-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.5.R1545"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1986.250.2.H173"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00591.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09030162.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191711043"},{"key":"e_1_2_7_11_1","first-page":"1","article-title":"Fetal glucose availability: A key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart","author":"Bertossa M. R.","year":"2025","journal-title":"The Journal of Physiology"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.047928"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000531"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01607.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.165944"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.112797"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19850072"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07010005.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP287171"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP279054"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.274.1.E13"},{"issue":"1","key":"e_1_2_7_22_1","first-page":"H17","article-title":"Autonomic mechanisms in the ductus venosus of the lamb","volume":"247","author":"Coceani F.","year":"1984","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103530"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhevol.2014.05.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.080523"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275806"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1340012"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280019"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280693"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15749"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP285572"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2005.05.003"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.06.003"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1976.230.1.1"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00273.2017"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340903214924"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.42.3.426"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1980.238.5.H656"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0561a.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13782"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.073569"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019521"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041759"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15884"},{"key":"e_1_2_7_45_1","unstructured":"Great Britain. Ministry of Agriculture Fisheries and Food. (1984).Energy Allowances and Feeding Systems for Ruminants. 2nd ed. Her Majesty's Stationery Office."},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP085299"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22329"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1990.259.6.R1126"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.17"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.5.E746"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000152391.45273.A2"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2024.01.020"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00781-x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.18.5.565"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.082798ni"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/iox174"},{"key":"e_1_2_7_57_1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1152\/jappl.1977.43.6.1080","article-title":"Fetal cerebral oxygen consumption at different levels of oxygenation","volume":"43","author":"Jones M. D.","year":"1977","journal-title":"Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318163a1de"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181a29077"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.1999.012"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00872.x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2784"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.3.H1166"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70442-3"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197212000-00006"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00553.2013"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00208"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13363"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600094"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.130"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120521"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198708000-00014"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.04975.x"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000526972"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0542"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0462"},{"key":"e_1_2_7_77_1","first-page":"141","article-title":"Maternal nutrition and the programming of obesity: The brain","volume":"2","author":"Muhlhausler B. S.","year":"2006","journal-title":"Organogenesis"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP286666"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216176"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn812"},{"key":"e_1_2_7_81_1","article-title":"Umbilical and hepatic venous responses to circulating vasoconstrictive hormones in fetal lamb","author":"Paulick R. P.","year":"1991","journal-title":"American Journal of Physiology\u2010Heart and Circulatory Physiology"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00036.2014"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281292"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030220"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.23.2892"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.07.002"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281002"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP279725"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14999"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0512-5"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1986.251.5.R893"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1987.252.1.R7"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199712000-00015"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2012.01.013"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9044"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa180"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11060426.x"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2000.0585"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2003.00519.x"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0810"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2747"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.08.002"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000128983.54614.7E"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19175"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/17450390701780276"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15613955"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/af\/vfz019"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14365"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2003.09.007"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1080\/152165401753311780"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.709717"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900406R"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198912000-00009"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008551"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.87"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP288413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP288413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1113\/JP288413","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP288413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:39:07Z","timestamp":1785224347000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP288413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":115,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1113\/JP288413"],"URL":"https:\/\/doi.org\/10.1113\/jp288413","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"assertion":[{"value":"2024-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}