{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:17:34Z","timestamp":1783030654595,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2021TO16"],"award-info":[{"award-number":["2021TO16"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["01\u2010001\u20102024\u20100559"],"award-info":[{"award-number":["01\u2010001\u20102024\u20100559"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["01\u2010003\u20102024\u20100477"],"award-info":[{"award-number":["01\u2010003\u20102024\u20100477"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      In healthy human hearts, the T\u2010wave is concordant with the QRS\u2010complex, which is often explained by the negative relationship between the activation (AT) and repolarization time (RT). Delayed ventricular conduction is typically accompanied by discordant T\u2010waves, but the link to regional repolarization is unknown. The present study aimed to compare AT\u2010RT relationships in patients with narrow QRS\u2010complexes (nQRS)\n                      <jats:italic>vs<\/jats:italic>\n                      . patients with left bundle branch block (LBBB) or intraventricular conduction disturbances (IVCD) using electrocardiographic imaging to reconstruct epicardial unipolar electrograms. Evaluations included the slopes of AT\u2010RT relationships, maximum (max) AT and RT, ventricular electrical uncoupling (VEU; the difference of mean AT or RT between the left and right ventricle), and the standard deviation of AT (SDAT) and RT (SDRT). In nQRS patients, the AT\u2010RT slope was highly variable (\u22120.370\u00a0\u00b1\u00a01.125,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.193\u00a0\u00b1\u00a00.212), whereas it was consistently positive in IVCD and LBBB patients (1.220\u00a0\u00b1\u00a00.907 and 0.968\u00a0\u00b1\u00a00.325,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0172\u00a0\u00b1\u00a00.0254 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0219\u00a0\u00b1\u00a00.0657 respectively). Max AT, max RT, AT\u2010VEU, RT\u2010VEU, SDAT and SDRT were similar for IVCD and LBBB patients and significantly higher compared to nQRS patients. In patients with delayed ventricular activation, there was a positive association between AT\u2010VEU and RT\u2010VEU (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.549,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0149). The present study demonstrates that, in nQRS rhythms with concordant T\u2010waves, the physiological assumption that sites of late activation have shorter repolarization intervals might not be consistently present at the epicardium. Furthermore, delayed ventricular activation is associated with delayed completion of repolarization and a dyssynchronous activation is accompanied by a dyssynchronous repolarization.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16864-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>This study examines the relationships between activation and repolarization times in epicardial reconstructed unipolar electrograms derived from ECG\u2010imaging in patients with normal and delayed ventricular activation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In patients with a narrow QRS\u2010complex and concordant T\u2010waves on a 12\u2010lead ECG, ECG\u2010imaging reveals significant variability in the activation\u2013repolarization time relationship. The physiological assumption that late\u2010activated regions have a shorter repolarization interval may thus not always be valid on the epicardium.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Patients with delayed ventricular activation typically exhibit discordant T\u2010wave polarity on a 12\u2010lead ECG and consistently demonstrate a positive activation\u2013repolarization time relationship on ECG\u2010imaging: regions of early activation correspond to shorter repolarization intervals, whereas regions of late activation correspond to longer repolarization intervals.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp288569","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T23:26:12Z","timestamp":1753226772000},"page":"5378-5390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The influence of delayed ventricular activation on cardiac repolarization: Insights from electrocardiographic imaging"],"prefix":"10.1113","volume":"604","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-5769","authenticated-orcid":false,"given":"Karin C.","family":"Smits","sequence":"first","affiliation":[{"name":"Department of Physiology Maastricht University Medical Center, Cardiovascular Research Institute Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted E.M.","family":"Lempers","sequence":"additional","affiliation":[{"name":"Department of Physiology Maastricht University Medical Center, Cardiovascular Research Institute Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Strik","sequence":"additional","affiliation":[{"name":"University Hospital of Bordeaux, Electrophysiology and Heart Modelling Institute (IHU\u2010LIRYC)  Pessac\u2010 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-5498","authenticated-orcid":false,"given":"Job","family":"Stoks","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center, Cardiovascular Research Institute Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Meiburg","sequence":"additional","affiliation":[{"name":"Group SIMBIOTX, Institut de Recherche en Informatique et en Automatique (INRIA)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs J.M.","family":"Cluitmans","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center, Cardiovascular Research Institute Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-1598","authenticated-orcid":false,"given":"Paul G.A.","family":"Volders","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center, Cardiovascular Research Institute Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Vernooy","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center, Cardiovascular Research Institute Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits W.","family":"Prinzen","sequence":"additional","affiliation":[{"name":"Department of Physiology Maastricht University Medical Center, Cardiovascular Research Institute Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uy\u00ean Ch\u00e2u","family":"Nguy\u00ean","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center, Cardiovascular Research Institute Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020153"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht150"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2021.12.007"},{"key":"e_1_2_5_5_1","first-page":"232","article-title":"In vivo validation of electrocardiographic imaging","volume":"3","author":"Cluitmans M. J. M.","year":"2017","journal-title":"Journal of the American College of Cardiology: Clinical Electrophysiology"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.5.1412"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.60.5.424"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13817"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.2.379"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(77)90009-3"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14764"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2012.03.001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.02.056"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad144"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001622"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-018-1132-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2016.01.007"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.10.010"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.15.1496"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw446"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.12.005"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.791830"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00064.2009"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1011"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15882"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.279315"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.09.008"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1158003"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae172"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15581"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP288569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP288569","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP288569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:32:02Z","timestamp":1783027922000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP288569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":30,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1113\/JP288569"],"URL":"https:\/\/doi.org\/10.1113\/jp288569","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"2025-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}