{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:39:39Z","timestamp":1785371979471,"version":"3.55.0"},"reference-count":127,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>Ocular hypertension (OHT) caused by mechanical stress and chronic glucocorticoid exposure reduces the hydraulic permeability of the conventional outflow pathway and increases the risk for irreversible vision loss, yet healthy individuals experience nightly intraocular pressure (IOP) elevations without adverse lifetime effects. It is not known how mechanosensation regulates physiological <jats:italic>vs<\/jats:italic>. pathological OHT nor how it impacts permeability of the principal drainage pathway through the trabecular meshwork (TM). We report that OHT induced by the circadian rhythm, occlusion of the iridocorneal angle and glucocorticoids requires activation of transient receptor potential vanilloid isoform 4 (TRPV4), a stretch\u2010activated cation channel. Wild\u2010type mice responded to nocturnal topical administration of the agonist GSK1016790A with IOP lowering, whereas intracameral injection of the agonist elevated diurnal IOP. Microinjection of TRPV4 antagonists HC\u2010067047 and GSK2193874 lowered IOP during the nocturnal OHT phase and in hypertensive eyes treated with dexamethasone or injection of polystyrene microbeads. Conventional outflow\u2010specific <jats:italic>Trpv4<\/jats:italic> knockdown induced partial IOP lowering in mice with an occluded iridocorneal angle and protected retinal neurons from pressure injury. Indicating a central role for TRPV4\u2010dependent mechanosensing in trabecular outflow, HC\u2010067047 doubled the outflow facility in TM\u2010populated steroid\u2010treated 3\u2010D nanoscaffolds. Tonic TRPV4 signalling thus represents a fundamental property of TM biology as a driver of increased <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> outflow resistance. The TRPV4 dependence of OHT under conditions that mimic primary and secondary glaucomas could be explored as a novel target for glaucoma treatments.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp16841-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Transient receptor potential vanilloid isoform 4 (TRPV4), a stretch\u2010activated channel, is required to maintain ocular hypertension (OHT) under physiological and pathological conditions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intraocular pressure elevations induced by occlusion of the iridocorneal angle, administration of steroid eye drops and circadian rhythmicity were blocked by TRPV4 antagonists and mimicked with a TRPV4 agonist.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TRPV4 inhibition suppressed steroid\u2010induced increases in outflow resistance in an <jats:italic>in vitro<\/jats:italic> biomimetic model of trabecular outflow.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Conditional ablation of TRPV4 channels from the trabecular meshwork prevented the induction of OHT and protected the eye from glaucoma.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These findings bring physiological and pathological mechanisms that mediate OHT into mechanobiological context and identify a novel target for pressure control in glaucoma.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1113\/jp288706","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T17:48:57Z","timestamp":1752169737000},"page":"4091-4111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["TRPV4 controls circadian and pathological ocular hypertension"],"prefix":"10.1113","volume":"603","author":[{"given":"Sarah N.","family":"Redmon","sequence":"first","affiliation":[{"name":"Department of Ophthalmology &amp; 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