{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:17:22Z","timestamp":1790561842665,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Calcium\u2010activated Cl<jats:sup>\u2212<\/jats:sup> channels (CaCC) are widely expressed proteins which regulate various physiological functions. TMEM16A is a CaCC expressed in the gastrointestinal and cardiovascular systems, where it is a major regulator of tissue contraction. In this review we discuss recent advances on the roles of TMEM16A in gastrointestinal and vascular smooth muscle contractility, including its segment and cell type\u2010specific effects. We also discuss recent physiological and pharmacological evidence suggesting potential therapeutic utility of TMEM16A modulators in gastrointestinal and cardiovascular diseases associated with altered smooth muscle contractility.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70106-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp289160","type":"journal-article","created":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T17:54:51Z","timestamp":1757872491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["TMEM16A in gastrointestinal and vascular smooth muscle contractility"],"prefix":"10.1113","author":[{"given":"Sadik Taskin","family":"Tas","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc O.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California  San Francisco California USA"},{"name":"Department of Chemistry and Biochemistry San Francisco State University  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5178-0199","authenticated-orcid":false,"given":"Onur","family":"Cil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202213217"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17383"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.06.006"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000967"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14598"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2021.102472"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2024.102990"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20746"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13201"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.277145"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163518"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00113.2007"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900858R"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.03.025"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273618"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15507.x"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00018.2010"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02199.x"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.043208"},{"issue":"34","key":"e_1_2_2_21_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023572118","article-title":"An outer\u2010pore gate modulates the pharmacology of the TMEM16A channel","volume":"118","author":"Dinsdale R. 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