{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:04:23Z","timestamp":1791821063320,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Regular physical activity is an important treatment component for chronic pain. To unravel the neuronal influence of exercise on pain, we investigated the neuronal changes during exercise\u2010induced hypoalgesia in endurance athletes and controls. Twenty\u2010two athletes (mean age: 33.3 \u00b1 10.8 years) and 20 non\u2010athletes (mean age: 28.9 \u00b1 9.0 years) underwent high\u2010intensity interval training (HIIT) and pressure pain tests, while brain oxygenation was monitored using functional near\u2010infrared spectroscopy to cover key regions of pain processing: the prefrontal cortex (PFC), sensorimotor cortices and posterior parietal cortex (PPC). During HIIT both groups exhibited a steady increase in PFC oxyhaemoglobin, with athletes showing a greater increase in the PPC area than non\u2010athletes. As expected athletes showed a significant reduction in pain perception after HIIT, whereas non\u2010athletes did not. In line with this athletes showed a significant decrease in oxyhaemoglobin levels in all brain areas post\u2010HIIT, whereas non\u2010athletes only showed a decrease in sensorimotor areas. Interestingly, in athletes, pain reduction correlated with the decrease in PFC oxyhaemoglobin during painful stimulation, whereas no significant correlation was observed in non\u2010athletes. The pronounced HIIT\u2010induced increase in oxyhaemoglobin in athletes may elevate baseline neural activity to a level where additional activation is limited, potentially reducing the salience of pain\u2010related signals. This athlete\u2010specific response may result from endurance training adaptations, such as enhanced microvascularization and oxygen delivery, promoting greater neural efficiency during high\u2010intensity exercise. These findings highlight HIIT's potential as a targeted pain management strategy for athletes and the need for tailored approaches in non\u2010athletes.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70422-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Regular physical activity is known to reduce pain, but the brain mechanisms behind this effect are not well understood, especially in trained compared with untrained people.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We studied how the brain responds to short bouts of very intense exercise and how this relates to pain perception in endurance athletes and non\u2010athletes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>During exercise athletes showed a stronger increase in oxygen supply in brain regions involved in attention and body awareness than non\u2010athletes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Only athletes experienced reduced pain after exercise, which was linked to lower activity in the frontal brain regions during painful stimulation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These results suggest that long\u2010term endurance training changes how the brain processes pain during and after exercise, which may help design more effective exercise\u2010based pain treatments for different populations.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp289766","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:54:37Z","timestamp":1772960077000},"page":"2738-2756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Profound neuronal differences during exercise\u2010induced hypoalgesia between athletes and non\u2010athletes revealed by functional near\u2010infrared spectroscopy"],"prefix":"10.1113","volume":"604","author":[{"given":"Maria","family":"Geisler","sequence":"first","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy University Hospital Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Herbsleb","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy University Hospital Jena  Jena Germany"},{"name":"Department of Sports Medicine and Health Promotion Friedrich\u2010Schiller\u2010University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feliberto","family":"de la Cruz","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy University Hospital Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"von Au","sequence":"additional","affiliation":[{"name":"Department of Neurology, 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