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These conditions represent a significant global health burden and often share common risk factors such as obesity, high cholesterol and insulin resistance. Cardiometabolic diseases include conditions such as hypertension, diabetes, heart failure, coronary artery disease and stroke. Recent advancements in molecular biology have highlighted the pivotal role of circular RNAs (circRNAs) in the regulation of gene expression and cellular processes. These stable, covalently closed RNA molecules act as microRNA sponges, modulating the activity of key metabolic and cardiovascular pathways. This review explores the emerging potential of circRNAs as novel therapeutic targets in cardiometabolic disease, focusing on the mechanisms by which circRNAs influence disease progression, their utility as biomarkers for early diagnosis and prognosis and the innovative therapeutic strategies being developed to harness their regulatory functions. However research into circRNAs also comes with its unique set of challenges, relating to detection, quantification, annotation variability and functional characterisation. Despite these challenges the potential for circRNAs to advance understanding and treatment of disease continues to drive research forward, paving the way for new diagnostic and therapeutic strategies to better manage cardiometabolic diseases.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70415-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp289839","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:25:23Z","timestamp":1773005123000},"page":"7047-7058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Circular RNAs: Unlocking new avenues in cardiometabolic disease management"],"prefix":"10.1113","volume":"604","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-9365","authenticated-orcid":false,"given":"Kimberley M.","family":"Mellor","sequence":"first","affiliation":[{"name":"Department of Physiology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9168-123X","authenticated-orcid":false,"given":"Thomas D.","family":"Donelly","sequence":"additional","affiliation":[{"name":"School of Exercise and Nutrition Sciences, Faculty of Health Deakin University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald L.M.","family":"Naepi","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6617-4359","authenticated-orcid":false,"given":"Glenn D.","family":"Wadley","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health Deakin University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4534-0549","authenticated-orcid":false,"given":"Bianca C.","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health Deakin University  Melbourne Victoria Australia"},{"name":"Department of Cardiometabolic Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.08.019"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115461"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07540"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.03.005"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.107"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16434"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26115138"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.04.045"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2025.102687"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0243-y"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwae281"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-024-00721-7"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HCG.0000000000000062"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-023-01476-0"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11233"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2023.2185764"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-020-00817-7"},{"key":"e_1_2_2_19_1","first-page":"1402","article-title":"Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses","volume":"38","author":"Du W. 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