{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:27:28Z","timestamp":1788276448791,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["CN_00000013"],"award-info":[{"award-number":["CN_00000013"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Arterial hypertension is a prevalent condition and a major risk factor for cardiovascular and neurological diseases. Notably, medical treatment fails to control blood pressure in a large proportion of diagnosed subjects, highlighting gaps in our understanding of hypertension's pathophysiology. Using a mathematical model of the human cardiovascular system, we quantify the contributions of various cardiovascular compartments to the hypertensive state. The impact of uncertainty in modelling assumptions is assessed through stochastic modelling. Our results show that reduced venous vascular compliance significantly increases arterial pressure, making it the second most influential factor in determining hypertension, after increased peripheral resistance.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70696-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We used a closed\u2010loop mathematical model of the full human circulation to simulate adaptation to hypertension, including stochastic variation in\u00a0parameters.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The model quantifies the relative importance of different cardiovascular parameters in determining arterial\u00a0pressure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Venous compliance emerged as the second most influential determinant of arterial pressure, after systemic\u00a0resistance.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Reduced venous compliance alone was sufficient to cause a hypertensive state in the\u00a0model.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These findings highlight the potential of the venous system as a novel therapeutic target for blood pressure regulation.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp289895","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:10:46Z","timestamp":1785489046000},"page":"7145-7160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the role of the venous system in arterial hypertension: A computational study"],"prefix":"10.1113","volume":"604","author":[{"given":"Eleuterio F.","family":"Toro","sequence":"first","affiliation":[{"name":"Laboratory of Applied Mathematics, Department of Civil, Environmental and Mechanical Engineering University of Trento Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas O.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Laboratory of Mathematics for Biology and Medicine, Department of Mathematics University of Trento Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonja W.","family":"Emans","sequence":"additional","affiliation":[{"name":"The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-9101","authenticated-orcid":false,"given":"Fiona D.","family":"McBryde","sequence":"additional","affiliation":[{"name":"The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-2913","authenticated-orcid":false,"given":"Julian F. 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