{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:40:21Z","timestamp":1792658421471,"version":"4.5.0"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2022\u2010138236NB\u2010I00"],"award-info":[{"award-number":["PID2022\u2010138236NB\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RYC2022\u2010035546\u2010I"],"award-info":[{"award-number":["RYC2022\u2010035546\u2010I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2024\u2010155362NA\u2010I00"],"award-info":[{"award-number":["PID2024\u2010155362NA\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      The intracardiac nervous system is a complex neural network formed by a diffuse plexus, the so\u2010called intracardiac ganglion (ICG). These ganglia locally innervate and control heart function, but little is known about how ICG neuronal activity is regulated. Although various ionic currents have been characterized in cardiac tissue, the expression and role of TWIK\u2010related K\n                      <jats:sup>+<\/jats:sup>\n                      (TREK) channels in ICG neurons remain unexplored. TREK channels, members of the two\u2010pore domain potassium channel family, are essential regulators of neuronal membrane resting potential and excitability, with recognized neuroprotective functions. In this study, we have characterized different ionic currents present in mouse ICG neurons, including tetrodotoxin\u2010sensitive Na\n                      <jats:sup>+<\/jats:sup>\n                      currents, delayed K\n                      <jats:sup>+<\/jats:sup>\n                      rectifiers, Ca\n                      <jats:sup>+2<\/jats:sup>\n                      \u2010dependent K\n                      <jats:sup>+<\/jats:sup>\n                      currents and A, H and M currents. Notably, we provide the first evidence of functional TREK channel expression in these neurons. Our findings suggest that TREK channels contribute to excitability control and cellular homoeostasis in ICG neurons, highlighting their potential relevance to cardiac physiology and disease.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70861-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            This study provides the first evidence of functional TWIK\u2010related K\n                            <jats:sup>+<\/jats:sup>\n                            (TREK) channel expression in intracardiac ganglion (ICG) neurons.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Comprehensive profiling of ionic currents shaping excitability in ICG neurons.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Neuroprotective TREK channels might emerge as potential therapeutic targets for cardiac disorders.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp290107","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:02:11Z","timestamp":1792656131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of TREK channels in mouse intracardiac ganglion neurons"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-6345","authenticated-orcid":false,"given":"Ana","family":"Campos\u2010Rios","sequence":"first","affiliation":[{"name":"Universidade de Vigo Department of Functional Biology and Health Sciences  Vigo Spain"},{"name":"CINBIO Universidade de Vigo  Vigo Spain"},{"name":"Laboratory of neuroscience Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS\u2010UVIGO  Vigo 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